The tubulin code and its role in controlling microtubule properties and functions

C Janke, MM Magiera - Nature Reviews Molecular Cell Biology, 2020 - nature.com
Microtubules are core components of the eukaryotic cytoskeleton with essential roles in cell
division, shaping, motility and intracellular transport. Despite their functional heterogeneity …

The tubulin code in microtubule dynamics and information encoding

A Roll-Mecak - Developmental cell, 2020 - cell.com
Microtubules are non-covalent mesoscale polymers central to the eukaryotic cytoskeleton.
Microtubule structure, dynamics, and mechanics are modulated by a cell's choice of tubulin …

Intrinsic and extrinsic factors affecting microtubule dynamics in normal and cancer cells

F Borys, E Joachimiak, H Krawczyk, H Fabczak - Molecules, 2020 - mdpi.com
Microtubules (MTs), highly dynamic structures composed of α-and β-tubulin heterodimers,
are involved in cell movement and intracellular traffic and are essential for cell division …

The neurodevelopmental disorder risk gene DYRK1A is required for ciliogenesis and control of brain size in Xenopus embryos

HR Willsey, Y Xu, A Everitt, J Dea, CRT Exner… - …, 2020 - journals.biologists.com
ABSTRACT DYRK1A [dual specificity tyrosine-(Y)-phosphorylation-regulated kinase 1 A] is
a high-confidence autism risk gene that encodes a conserved kinase. In addition to autism …

Modeling Down syndrome in animals from the early stage to the 4.0 models and next

MMM Moreno, V Brault, MC Birling, G Pavlovic… - Progress in brain …, 2020 - Elsevier
The genotype–phenotype relationship and the physiopathology of Down Syndrome (DS)
have been explored in the last 20 years with more and more relevant mouse models. From …

The ELAV/Hu protein Found in neurons regulates cytoskeletal and ECM adhesion inputs for space-filling dendrite growth

RA Alizzi, D Xu, CM Tenenbaum, W Wang… - PLoS genetics, 2020 - journals.plos.org
Dendritic arbor morphology influences how neurons receive and integrate extracellular
signals. We show that the ELAV/Hu family RNA-binding protein Found in neurons (Fne) is …

Conserved Tao kinase activity regulates dendritic arborization, cytoskeletal dynamics, and sensory function in Drosophila

C Hu, AK Kanellopoulos, M Richter… - Journal of …, 2020 - Soc Neuroscience
Dendritic arborization is highly regulated and requires tight control of dendritic growth,
branching, cytoskeletal dynamics, and ion channel expression to ensure proper function …

[HTML][HTML] In vitro reconstitution and imaging of microtubule dynamics by fluorescence and label-free microscopy

WG Hirst, C Kiefer, MK Abdosamadi, E Schäffer… - STAR protocols, 2020 - Elsevier
Dynamic microtubules are essential for many processes in the lives of eukaryotic cells. To
study and understand the mechanisms of microtubule dynamics and regulation, in vitro …

[PDF][PDF] Mechanisms and functions of the tubulin code 1 2 3 4

C Janke, MM Magiera - Nature Reviews Molecular Cell Biology, 2020 - hal.science
Microtubules are core components of the eukaryotic cytoskeleton with essential roles in cell
12 division, shaping, intracellular transport, and motility. Despite their functional …

Proteomics study of peripheral blood mononuclear cells in Down syndrome children

C Lanzillotta, V Greco, D Valentini, A Villani, V Folgiero… - Antioxidants, 2020 - mdpi.com
Down syndrome (DS) is the most common chromosomal disorder and the leading genetic
cause of intellectual disability in humans, which results from the triplication of chromosome …