Molecular inputs to chromatin via cellular metabolism are modifiers of the epigenome. These
inputs—which include both nutrient availability as a result of diet and growth factor signalling …

Background Many metabolites serve as important signalling molecules to adjust cellular
activities and functions based on nutrient availability. Links between acetyl-CoA metabolism …

Lysine acetylation is a conserved, reversible, post-translational protein modification
regulated by lysine acetyltransferases (KATs) and lysine deacetylases (KDACs; also known …

Acetate is a major end product of bacterial fermentation of fiber in the gut. Acetate, whether
derived from the diet or from fermentation in the colon, has been implicated in a range of …

Cardiovascular diseases (CVDs) are the leading cause of morbidity and mortality worldwide.
Metabolic dysfunction is a fundamental core mechanism underlying CVDs. Previous studies …

Metabolites affect cell growth in two different ways. First, they serve as building blocks for
biomass accumulation. Second, metabolites regulate the activity of growth-relevant …

Previously, we reported that chromodomain Y–like (CDYL) acts as a crotonyl–coenzyme A
hydratase and negatively regulates histone crotonylation (Kcr). However, the global CDYL …

While metabolism was initially thought to play a passive role in cell biology by generating
ATP to meet bioenergetic demands, recent studies have identified critical roles for …

Background Virtually all eukaryotic cells contain spatially distinct genomes, a single nuclear
genome that harbours the vast majority of genes and much smaller genomes found in …

Many chromatin-modifying enzymes require metabolic cofactors to support their catalytic
activities, providing a direct path for fluctuations in metabolite availability to regulate the …