Synthetic 3D extracellular matrices (ECMs) find application in cell studies, regenerative
medicine, and drug discovery. While cells cultured in a monolayer may exhibit unnatural …

The metalloproteinase (MP) family of zinc-dependent proteases, including matrix
metalloproteinases (MMPs), a disintegrin and metalloproteases (ADAMs), and a disintegrin …

The lack of in vitro tissue and organ models capable of mimicking human physiology
severely hinders the development and clinical translation of therapies and drugs with higher …

Microvasculature functions at the tissue and cell level, regulating local mass exchange of
oxygen and nutrient-rich blood. While there has been considerable success in the …

The specific microenvironment that cells reside in fundamentally impacts their broader
function in tissues and organs. At its core, this microenvironment is composed of precise …

Injectable materials represent very attractive ready‐to‐use biomaterials for application in
minimally invasive surgical procedures. It is shown that this approach to treat, for example …

Conspectus In this Account, we describe the organization of functional peptides as densely
arrayed side chains on polymer scaffolds which we introduce as a new class of material …

Due to their selective crosslinking chemistry and well‐defined mechano‐biochemical
characteristics, hydrogels crosslinked by thiol‐Michael addition reactions have garnered …

In the primordial cell encapsulation systems, the main goal is to treat endocrine diseases
avoiding the action of the immune system. Although lessons afforded by such systems are of …

Thiol-maleimide and thiol-vinylsulfone cross-linked hydrogels are widely used systems in
3D culture models, in spite of presenting uncomfortable reaction kinetics for cell …