Infection as a stroke risk factor and determinant of outcome after stroke

MSV Elkind, AK Boehme, CJ Smith, A Meisel… - Stroke, 2020 - Am Heart Assoc
Understanding the relationship between infection and stroke has taken on new urgency in
the era of the coronavirus disease 2019 (COVID-19) pandemic. This association is not a …

Multilevel omics for the discovery of biomarkers and therapeutic targets for stroke

J Montaner, L Ramiro, A Simats, S Tiedt… - Nature Reviews …, 2020 - nature.com
Despite many years of research, no biomarkers for stroke are available to use in clinical
practice. Progress in high-throughput technologies has provided new opportunities to …

The role of selected pro-inflammatory cytokines in pathogenesis of ischemic stroke

H Pawluk, A Woźniak, G Grześk… - … interventions in aging, 2020 - Taylor & Francis
Stroke is currently one of the most common causes of death and disability in the world, and
its pathophysiology is a complex process, involving the oxidative stress and inflammatory …

Mesenchymal Stromal Cell–Derived Small Extracellular Vesicles Induce Ischemic Neuroprotection by Modulating Leukocytes and Specifically Neutrophils

C Wang, V Börger, M Sardari, F Murke, J Skuljec, R Pul… - Stroke, 2020 - Am Heart Assoc
Background and Purpose—Small extracellular vesicles (sEVs) obtained from mesenchymal
stromal cells (MSCs) were shown to induce neurological recovery after focal cerebral …

Nanomedicine for ischemic stroke

X Dong, J Gao, Y Su, Z Wang - International Journal of Molecular …, 2020 - mdpi.com
Stroke is a severe brain disease leading to disability and death. Ischemic stroke dominates
in stroke cases, and there are no effective therapies in clinic, partly due to the challenges in …

[HTML][HTML] Heterogeneity in brain distribution of activated microglia and astrocytes in a rat ischemic model of Alzheimer's disease after 2 years of survival

L Radenovic, M Nenadic, M Ułamek-Kozioł… - Aging (albany …, 2020 - ncbi.nlm.nih.gov
The present study was designed to follow neuroinflammation after ischemic brain injury in
the long-term survival rat model. Immunohistochemistry was performed 2 years after 10 min …

Management of dysphagia in patients with Parkinson's disease and related disorders

G Umemoto, H Furuya - Internal Medicine, 2020 - jstage.jst.go.jp
Various methods of rehabilitation for dysphagia have been suggested through the
experience of treating stroke patients. Although most of these patients recover their …

B cells migrate into remote brain areas and support neurogenesis and functional recovery after focal stroke in mice

SB Ortega, VO Torres, SE Latchney… - Proceedings of the …, 2020 - National Acad Sciences
Lymphocytes infiltrate the stroke core and penumbra and often exacerbate cellular injury. B
cells, however, are lymphocytes that do not contribute to acute pathology but can support …

Dectin-1/Syk signaling triggers neuroinflammation after ischemic stroke in mice

XC Ye, Q Hao, WJ Ma, QC Zhao, WW Wang… - Journal of …, 2020 - Springer
Background Dendritic cell-associated C-type lectin-1 (Dectin-1) receptor has been reported
to be involved in neuroinflammation in Alzheimer's disease and traumatic brain injury. The …

Natalizumab in acute ischemic stroke (ACTION II) A randomized, placebo-controlled trial

MSV Elkind, R Veltkamp, J Montaner, SC Johnston… - Neurology, 2020 - AAN Enterprises
Objective We evaluated the effect of 2 doses of natalizumab on functional outcomes in
patients with acute ischemic stroke (AIS). Methods In this double-blind phase 2b trial …