Mitochondrial dysfunction in fibrotic diseases
X Li, W Zhang, Q Cao, Z Wang, M Zhao, L Xu… - Cell death …, 2020 - nature.com
Although fibrosis is a common pathological feature of most end-stage organ diseases, its
pathogenesis remains unclear. There is growing evidence that mitochondrial dysfunction …
pathogenesis remains unclear. There is growing evidence that mitochondrial dysfunction …
Melatonin and circadian rhythms in liver diseases: Functional roles and potential therapies
Circadian rhythms and clock gene expressions are regulated by the suprachiasmatic
nucleus in the hypothalamus, and melatonin is produced in the pineal gland. Although the …
nucleus in the hypothalamus, and melatonin is produced in the pineal gland. Although the …
Melatonin protects mouse testes from palmitic acid‐induced lipotoxicity by attenuating oxidative stress and DNA damage in a SIRT1‐dependent manner
D Xu, L Liu, Y Zhao, L Yang, J Cheng… - Journal of Pineal …, 2020 - Wiley Online Library
Palmitic acid (PA), the main component of dietary saturated fat, has been known to increase
in patients with obesity, and PA‐induced lipotoxicity may contribute to obesity‐related male …
in patients with obesity, and PA‐induced lipotoxicity may contribute to obesity‐related male …
Study on the attenuated effect of Ginkgolide B on ferroptosis in high fat diet induced nonalcoholic fatty liver disease
Y Yang, J Chen, Q Gao, X Shan, J Wang, Z Lv - Toxicology, 2020 - Elsevier
Ginkgolide B (GB), a main constituent of Ginkgo biloba extracts, reduces hepatic lipid
accumulation and ameliorates nonalcoholic fatty liver disease (NAFLD) in obese mice, but …
accumulation and ameliorates nonalcoholic fatty liver disease (NAFLD) in obese mice, but …
Melatonin alleviates Neuroinflammation and metabolic disorder in DSS‐induced depression rats
W Lv, C Liu, L Yu, J Zhou, Y Li, Y Xiong… - Oxidative medicine …, 2020 - Wiley Online Library
There is a bidirectional relationship between inflammatory bowel disease (IBD) and
depression/anxiety. Emerging evidences indicate that the liver may be involved in …
depression/anxiety. Emerging evidences indicate that the liver may be involved in …
Imbalance in mitochondrial dynamics induced by low PGC-1α expression contributes to hepatocyte EMT and liver fibrosis
L Zhang, Y Zhang, X Chang, X Zhang - Cell death & disease, 2020 - nature.com
An imbalance in mitochondrial dynamics induced by oxidative stress may lead to hepatocyte
epithelial mesenchymal transition (EMT) and liver fibrosis. However, the underlying …
epithelial mesenchymal transition (EMT) and liver fibrosis. However, the underlying …
Obesity caused by a high-fat diet regulates the Sirt1/PGC-1α/FNDC5/BDNF pathway to exacerbate isoflurane-induced postoperative cognitive dysfunction in older …
Z Zhao, M Yao, L Wei, S Ge - Nutritional neuroscience, 2020 - Taylor & Francis
Objectives: To investigate the effects of obesity caused by high-fat diet (HFD) on
postoperative cognitive dysfunction (POCD) and expression of the Sirt1/PGC …
postoperative cognitive dysfunction (POCD) and expression of the Sirt1/PGC …
MicroRNA-98 inhibits hepatic stellate cell activation and attenuates liver fibrosis by regulating HLF expression
Q Wang, S Wei, H Zhou, L Li, S Zhou, C Shi… - Frontiers in Cell and …, 2020 - frontiersin.org
Liver fibrosis is a major endpoint of patients with chronic liver diseases. The molecular
mechanisms behind liver fibrosis remain largely unknown. Many studies have indicated the …
mechanisms behind liver fibrosis remain largely unknown. Many studies have indicated the …
[HTML][HTML] The effect of matrix stiffness on human hepatocyte migration and function—an in vitro research
T Xia, R Zhao, F Feng, L Yang - Polymers, 2020 - mdpi.com
The extracellular matrix (ECM) regulates cellular function through the dynamic
biomechanical and biochemical interplay between the resident cells and their …
biomechanical and biochemical interplay between the resident cells and their …
Yap-Hippo pathway regulates cerebral hypoxia-reoxygenation injury in neuroblastoma N2a cells via inhibiting ROCK1/F-actin/mitochondrial fission pathways
C Geng, J Wei, C Wu - Acta Neurologica Belgica, 2020 - Springer
Abstract Yes-associated protein (Yap), a regulator of cellular apoptosis, has been
demonstrated to be involved in cerebral ischemia–reperfusion (IR) injury through poorly …
demonstrated to be involved in cerebral ischemia–reperfusion (IR) injury through poorly …