Although fibrosis is a common pathological feature of most end-stage organ diseases, its
pathogenesis remains unclear. There is growing evidence that mitochondrial dysfunction …

Circadian rhythms and clock gene expressions are regulated by the suprachiasmatic
nucleus in the hypothalamus, and melatonin is produced in the pineal gland. Although the …

Palmitic acid (PA), the main component of dietary saturated fat, has been known to increase
in patients with obesity, and PA‐induced lipotoxicity may contribute to obesity‐related male …

Ginkgolide B (GB), a main constituent of Ginkgo biloba extracts, reduces hepatic lipid
accumulation and ameliorates nonalcoholic fatty liver disease (NAFLD) in obese mice, but …

There is a bidirectional relationship between inflammatory bowel disease (IBD) and
depression/anxiety. Emerging evidences indicate that the liver may be involved in …

An imbalance in mitochondrial dynamics induced by oxidative stress may lead to hepatocyte
epithelial mesenchymal transition (EMT) and liver fibrosis. However, the underlying …

Objectives: To investigate the effects of obesity caused by high-fat diet (HFD) on
postoperative cognitive dysfunction (POCD) and expression of the Sirt1/PGC …

Liver fibrosis is a major endpoint of patients with chronic liver diseases. The molecular
mechanisms behind liver fibrosis remain largely unknown. Many studies have indicated the …

The extracellular matrix (ECM) regulates cellular function through the dynamic
biomechanical and biochemical interplay between the resident cells and their …

Abstract Yes-associated protein (Yap), a regulator of cellular apoptosis, has been
demonstrated to be involved in cerebral ischemia–reperfusion (IR) injury through poorly …