The adenosine pathway in immuno-oncology
Cancer immunotherapy based on immune-checkpoint inhibition or adoptive cell therapy has
revolutionized cancer care. Nevertheless, a large proportion of patients do not benefit from …
revolutionized cancer care. Nevertheless, a large proportion of patients do not benefit from …
Immunity, hypoxia, and metabolism–the Ménage à Trois of cancer: implications for immunotherapy
C Riera-Domingo, A Audigé, S Granja… - Physiological …, 2020 - journals.physiology.org
It is generally accepted that metabolism is able to shape the immune response. Only
recently we are gaining awareness that the metabolic crosstalk between different tumor …
recently we are gaining awareness that the metabolic crosstalk between different tumor …
Damage-associated molecular patterns in tumor radiotherapy
Radiotherapy is one of the most common modalities for the treatment of cancer. One of the
most promising effects of radiotherapy is immunologic cell death and the release of danger …
most promising effects of radiotherapy is immunologic cell death and the release of danger …
CD73 blockade promotes dendritic cell infiltration of irradiated tumors and tumor rejection
E Wennerberg, S Spada, NP Rudqvist, C Lhuillier… - Cancer immunology …, 2020 - AACR
The ability of focal radiotherapy to promote priming of tumor-specific CD8+ T cells and
increase responses to immunotherapy is dependent on infiltration of the tumor by Batf3 …
increase responses to immunotherapy is dependent on infiltration of the tumor by Batf3 …
Myeloid PTEN promotes chemotherapy-induced NLRP3-inflammasome activation and antitumour immunity
PTEN is a dual-specificity phosphatase that is frequently mutated in human cancer, and its
deficiency in cancer has been associated with therapy resistance and poor survival …
deficiency in cancer has been associated with therapy resistance and poor survival …
[HTML][HTML] Purinergic signaling in the hallmarks of cancer
AR Campos-Contreras, M Díaz-Muñoz… - Cells, 2020 - mdpi.com
Cancer is a complex expression of an altered state of cellular differentiation associated with
severe clinical repercussions. The effort to characterize this pathological entity to understand …
severe clinical repercussions. The effort to characterize this pathological entity to understand …
Targeting innate sensing in the tumor microenvironment to improve immunotherapy
The innate immune sensing pathways play critical roles in the defense against pathogen
infection, but their roles in cancer immunosurveillance and cancer therapies are less …
infection, but their roles in cancer immunosurveillance and cancer therapies are less …
[HTML][HTML] Emerging potential of exosomes in regenerative medicine for temporomandibular joint osteoarthritis
Exosomes are nanosized vesicles (30–140 nm) of endocytic origin that play important roles
in regenerative medicine. They are derived from cell membranes during endocytic …
in regenerative medicine. They are derived from cell membranes during endocytic …
Radiation with STAT3 blockade triggers dendritic cell–T cell interactions in the glioma microenvironment and therapeutic efficacy
Purpose: Patients with central nervous system (CNS) tumors are typically treated with
radiotherapy, but this is not curative and results in the upregulation of phosphorylated …
radiotherapy, but this is not curative and results in the upregulation of phosphorylated …
[HTML][HTML] Pro-tumor γδ T cells in human cancer: polarization, mechanisms of action, and implications for therapy
G Chabab, C Barjon, N Bonnefoy, V Lafont - Frontiers in immunology, 2020 - frontiersin.org
The tumor immune microenvironment contributes to tumor initiation, progression and
response to therapy. Among the immune cell subsets that play a role in the tumor …
response to therapy. Among the immune cell subsets that play a role in the tumor …