Cancer complicates 1 in 1000 pregnancies. Multidisciplinary consensus comprised of
Gynecologic Oncology, Pathology, Neonatology, Radiology, Anesthesiology, Maternal Fetal …

Long acquisition times can limit the use of MRI in pediatric patients, and the use of sedation
or general anesthesia is frequently necessary to facilitate diagnostic examinations. The use …

Various lines of evidence suggest that neonatal exposure to general anesthetics, especially
repeatedly, results in neuropathological brain changes and long‐term cognitive impairment …

Background Inhibition of inositol-requiring enzyme-1 alpha (IRE1α), one of the sensor
signaling proteins associated with endoplasmic reticulum (ER) stress, has been shown to …

General anaesthesia may impose significant neurocognitive risks on the developing brain.
As brain injury in preterm neonates has a particular predilection for cerebral white matter, we …

Despite tremendous advances in neonatal intensive care over the past 20 years, prematurity
carries a high burden of neurological morbidity lasting lifelong. The term encephalopathy of …

Summary In March 2019, SmartTots, a public–private partnership between the US Food and
Drug Administration and the International Anesthesia Research Society, hosted a meeting …

Recent advances in image reconstruction techniques have enabled high resolution MRI
studies of fetal brain development in human subjects. Rhesus macaques (Macaca mulatta) …

Sevoflurane, which is widely used in paediatric anaesthesia, induces neural apoptosis in the
developing brain and cognitive impairment in young mammals. Glucose hypometabolism is …

BACKGROUND The concept of anaesthesia-related neonatal neurotoxicity originated in
neonatal rodent models, yet prospective clinical studies have largely not supported this …