Epigenetic dysregulation has long been recognized as a key factor contributing to
tumorigenesis and tumour maintenance that can influence all of the recognized hallmarks of …

Cells have a remarkable ability to synthesize large amounts of protein in a very short period
of time. Under these conditions, many hydrophobic surfaces on proteins may be transiently …

Histone deacetylases (HDACs) are a class of enzymes that remove acetyl from the ε-N-
acetyl lysine of histones, allowing histones to wrap DNA more tightly. HDACs play an …

Histone deacetylase 6 (HDAC6) is involved in multiple cellular processes such as
aggresome formation, protein stability, and cell motility. Numerous HDAC6-selective …

Peripheral T-cell lymphoma (PTCL) is a rare and heterogeneous group of clinically
aggressive diseases associated with poor prognosis. Except for ALK+ anaplastic large-cell …

Reversal of aging symptoms and related disorders are the challenging task where
epigenetic is a crucial player that includes DNA methylation, histone modification; chromatin …

Despite the applicability of histone deacetylase inhibitors (HDACis) for cancer treatment,
several works in the literature have shown that these inhibitors can be used in several other …

Epigenetic modulation, including acetylation, methylation, phosphorylation, and
ubiquitination, plays a pivotal role in regulation of gene expression. Histone acetylation—a …

Upregulation of heat shock proteins (HSPs) is an approach to treatment of
neurodegenerative disorders with impaired proteostasis. Many neurons, including motor …

The tyrosine kinase inhibitors (TKIs) have revolutionized the management of chronic
myeloid leukemia (CML) and BCR-ABL1 inhibitors form the mainstay of CML treatment …