Executive summary The number of older people, including those living with dementia, is
rising, as younger age mortality declines. However, the age-specific incidence of dementia …

Background Evidence on preventing Alzheimer's disease (AD) is challenging to interpret
due to varying study designs with heterogeneous endpoints and credibility. We completed a …

Alzheimer's disease (AD) and dementia are a global public health priority, and prevention
has been highlighted as a pivotal component in managing the dementia epidemic …

Poor diet and obesity are associated with cognitive impairment throughout adulthood, and
increased dementia risk in aging. Here we review the current literature interrogating the …

The complications associated with adult obesity are overwhelming national healthcare
systems. No country has yet implemented a successful population-level strategy to reverse …

Background Very few studies have explored the patterns of cardiovascular health (CVH)
metrics in midlife and late life in relation to risk of dementia. We examined the associations …

The number of people living with dementia and Alzheimer's disease is growing rapidly,
making dementia one of the biggest challenges for this century. Many studies have indicated …

Uncertainty exists regarding the relation of body size and weight change with dementia risk.
As populations continue to age and the global obesity epidemic shows no sign of waning …

Objective To help determine whether midlife obesity is a cause of dementia and whether low
body mass index (BMI), low caloric intake, and physical inactivity are causes or merely …

Importance Midlife vascular risk burden is associated with late-life dementia. Less is known
about if and how risk exposure in early adulthood influences late-life brain health. Objective …