[HTML][HTML] Revisiting pharmacology of oxidative stress and endothelial dysfunction in cardiovascular disease: Evidence for redox-based therapies
A Daiber, S Chlopicki - Free Radical Biology and Medicine, 2020 - Elsevier
According to the latest Global Burden of Disease Study data, non-communicable diseases in
general and cardiovascular disease (CVD) in particular are the leading cause of premature …
general and cardiovascular disease (CVD) in particular are the leading cause of premature …
On the clinical pharmacology of reactive oxygen species
Reactive oxygen species (ROS) have been correlated with almost every human disease. Yet
clinical exploitation of these hypotheses by pharmacological modulation of ROS has been …
clinical exploitation of these hypotheses by pharmacological modulation of ROS has been …
Effect of praliciguat on peak rate of oxygen consumption in patients with heart failure with preserved ejection fraction: the CAPACITY HFpEF randomized clinical trial
Importance Heart failure with preserved ejection fraction (HFpEF) is often characterized by
nitric oxide deficiency. Objective To evaluate the efficacy and adverse effects of praliciguat …
nitric oxide deficiency. Objective To evaluate the efficacy and adverse effects of praliciguat …
Enhanced cardiomyocyte function in hypertensive rats with diastolic dysfunction and human heart failure patients after acute treatment with soluble guanylyl cyclase …
D Kolijn, Á Kovács, M Herwig, M Lódi, M Sieme… - Frontiers in …, 2020 - frontiersin.org
Aims Our aim was to investigate the effect of nitric oxide (NO)-independent activation of
soluble guanylyl cyclase (sGC) on cardiomyocyte function in a hypertensive animal model …
soluble guanylyl cyclase (sGC) on cardiomyocyte function in a hypertensive animal model …
[HTML][HTML] Role of cyclic nucleotides and their downstream signaling cascades in memory function: Being at the right time at the right spot
EK Argyrousi, PRA Heckman, J Prickaerts - Neuroscience & Biobehavioral …, 2020 - Elsevier
A plethora of studies indicate the important role of cAMP and cGMP cascades in neuronal
plasticity and memory function. As a result, altered cyclic nucleotide signaling has been …
plasticity and memory function. As a result, altered cyclic nucleotide signaling has been …
Evaluation of high‐sensitivity C‐reactive protein and uric acid in vericiguat‐treated patients with heart failure with reduced ejection fraction
F Kramer, S Voss, L Roessig, BW Igl… - European journal of …, 2020 - Wiley Online Library
Aims The effects of vericiguat vs. placebo on high‐sensitivity C‐reactive protein (hsCRP)
and serum uric acid (SUA) were assessed in patients with heart failure with reduced ejection …
and serum uric acid (SUA) were assessed in patients with heart failure with reduced ejection …
Discovery of Novel Pyrazolo[3,4-b] Pyridine Derivatives with Dual Activities of Vascular Remodeling Inhibition and Vasodilation for the Treatment of Pulmonary …
Current pulmonary arterial hypertension (PAH) therapeutic strategies mainly focus on
vascular relaxation with less emphasis on vascular remodeling, which results in poor …
vascular relaxation with less emphasis on vascular remodeling, which results in poor …
Soluble guanylyl cyclase stimulation and phosphodiesterase-5 inhibition improve portal hypertension and reduce liver fibrosis in bile duct–ligated rats
K Brusilovskaya, P Königshofer… - United European …, 2020 - journals.sagepub.com
Background In cirrhosis, the nitric oxide-soluble guanylyl cyclase (sGC)-cyclic guanosine
monophosphate (cGMP) pathway is impaired, which contributes to increased intrahepatic …
monophosphate (cGMP) pathway is impaired, which contributes to increased intrahepatic …
Soluble guanylate cyclase stimulator praliciguat attenuates inflammation, fibrosis, and end-organ damage in the Dahl model of cardiorenal failure
CM Shea, GM Price, G Liu, R Sarno… - American Journal …, 2020 - journals.physiology.org
Reduced nitric oxide (NO) and a decrease in cGMP signaling mediated by soluble
guanylate cyclase (sGC) has been linked to the development of several cardiorenal …
guanylate cyclase (sGC) has been linked to the development of several cardiorenal …
cGMP signaling in cardiovascular diseases: linking genotype and phenotype
TA Dang, H Schunkert, T Kessler - Journal of Cardiovascular …, 2020 - journals.lww.com
Abstract Cyclic guanosine 3′, 5′-monophosphate (cGMP) is the key second messenger
molecule in nitric oxide signaling. Its rapid generation and fate, but also its role in mediating …
molecule in nitric oxide signaling. Its rapid generation and fate, but also its role in mediating …