Fibrosis is the abnormal deposition of extracellular matrix, which can lead to organ
dysfunction, morbidity, and death. The disease burden caused by fibrosis is substantial, and …

Alveolar epithelial type II cells (AT2) are a heterogeneous population that have critical
secretory and regenerative roles in the alveolus to maintain lung homeostasis. However …

Although fibrosis is a common pathological feature of most end-stage organ diseases, its
pathogenesis remains unclear. There is growing evidence that mitochondrial dysfunction …

Idiopathic pulmonary fibrosis (IPF) is a devastating lung disease of unknown etiology. It is
characterized by deposition of extracellular matrix proteins, like collagen and fibronectin in …

Mechanisms underlying the pathogenesis of pulmonary fibrosis remain incompletely
understood. Emerging evidence suggests changes in mitochondrial quality control are a …

Tissue stem cells undergo premature senescence under stress, promoting age-related
diseases; however, the associated mechanisms remain unclear. Here, we report that in …

Epithelial cell dysfunction has emerged as a central component of the pathophysiology of
diffuse parenchymal diseases including idiopathic pulmonary fibrosis (IPF). Alveolar type 2 …

Pulmonary fibrosis arises from the repeated epithelial mild injuries and insufficient repair
lead to over activation of fibroblasts and excessive deposition of extracellular matrix, which …

Pulmonary inflammatory responses lie under circadian control; however, the importance of
circadian mechanisms in the underlying fibrotic phenotype is not understood. Here, we …

The abnormal inflammatory responses due to the lung tissue damage and ineffective
repair/resolution in response to the inhaled toxicants result in the pathological changes …