Germinal centers and autoantibodies
Preventing self‐reactive lymphocytes from participating in effector responses is fundamental
to maintaining immunological self‐tolerance and circumventing autoimmunity. A range of …
to maintaining immunological self‐tolerance and circumventing autoimmunity. A range of …
[HTML][HTML] Affinity maturation is required for pathogenic monovalent IgG4 autoantibody development in myasthenia gravis
ML Fichtner, C Vieni, RL Redler, L Kolich… - Journal of Experimental …, 2020 - rupress.org
Disclosures: ML Fichtner reported grants from Grifols outside the submitted work. P.
Stathopoulos reported grants from Onassis Foundation outside the submitted work. RJ …
Stathopoulos reported grants from Onassis Foundation outside the submitted work. RJ …
Peripheral tolerance checkpoints imposed by ubiquitous antigen expression limit antigen-specific B cell responses under strongly immunogenic conditions
A series of layered peripheral checkpoints maintain self-reactive B cells in an unresponsive
state. Autoantibody production occurs when these checkpoints are breached; however …
state. Autoantibody production occurs when these checkpoints are breached; however …
Understanding gene mutations driving autoimmune disease and lymphoid malignancy.
E Masle-Farquhar - 2020 - unsworks.unsw.edu.au
The pathogenesis of autoimmune diseases is poorly understood-this is explicit in our failure
to effectively cure them. This thesis had two primary, interdependent, aims. The first was …
to effectively cure them. This thesis had two primary, interdependent, aims. The first was …