Cardiovascular diseases (CVDs) is the leading cause of high morbidity and mortality
worldwide, which emphasizes the urgent necessity to develop new pharmacotherapies. In …

Statin therapy is the gold standard in the treatment of dyslipidemia. Understanding the
mechanisms of action of these drugs provides an opportunity to define new therapeutic …

Implanted medical devices often elicit adverse foreign body responses whereby
macrophages play a central role. Here, we identify simple polymers that instruct different …

There is cumulating evidence for a contribution of Wnt signaling pathways in multiple
processes involved in atherosclerosis and vascular aging. Wnt signaling plays a role in …

Atherosclerosis, a pathology affecting large and medium-sized arteries, is the major cause of
cardiovascular morbidity/mortality in industrialized countries. During atherosclerosis, cells …

The Wnt signalling pathways are composed of a highly conserved cascade of events that
govern cell differentiation, apoptosis and cell orientation. Three major and distinct Wnt …

Abstract Dickkopf-1 (DKK-1) is a well-established inhibitor of canonical Wnt-signaling that
critically participates in the regulation of bone formation and has been implicated in the …

Aims Carotid intima-media thickness (cIMT) is a validated surrogate marker of
atherosclerosis. Dickkopf-1 (Dkk-1) and sclerostin modulate wingless signaling, which is …

Vascular calcification (VC), the ectopic deposition of calcium phosphate crystals in the
vessel wall, is one of the primary contributors to cardiovascular death. The pathology of VC …

Background Dickkopf‐1 and sclerostin have been implicated in atherosclerosis and vascular
calcification. We aimed to quantify the association of their serum levels with incident …