Ethnopharmacological relevance The global problem of diabetes, together with the limited
access of large numbers of patients to conventional antidiabetic medicines, continues to …

Diabetes and other lifestyle disorders have been recognized as the leading cause of
morbidity and mortality globally. Nuclear factor kappa B (NF-κB) is a major factor involved in …

Understanding the mechanisms that underlie the generation and regeneration of β cells is
crucial for developing treatments for diabetes. However, traditional research methods, which …

Diabetes is a major worldwide health problem which results from the loss and/or dysfunction
of pancreatic insulin-producing β cells in the pancreas. Therefore, there is great interest in …

We present a mathematical model of the energy-driven metabolic switch for glucagon and
insulin secretion from pancreatic alpha and beta cells, respectively. The energy status …

Cellular identity during development is under the control of transcription factors that form
gene regulatory networks. However, the transcription factors and gene regulatory networks …