Animal models of atrial fibrillation

D Schüttler, A Bapat, S Kääb, K Lee, P Tomsits… - Circulation …, 2020 - Am Heart Assoc
Atrial fibrillation (AF) is the most common sustained arrhythmia encountered in humans and
is a significant source of morbidity and mortality. Despite its prevalence, our mechanistic …

The role of cardiac macrophage and cytokines on ventricular arrhythmias

M Chen, X Li, S Wang, L Yu, J Tang, S Zhou - Frontiers in Physiology, 2020 - frontiersin.org
In the heart, cardiac macrophages have widespread biological functions, including roles in
antigen presentation, phagocytosis, and immunoregulation, through the formation of diverse …

Loss of SPEG inhibitory phosphorylation of ryanodine receptor type-2 promotes atrial fibrillation

HM Campbell, AP Quick, I Abu-Taha, DY Chiang… - Circulation, 2020 - Am Heart Assoc
Background: Enhanced diastolic calcium (Ca2+) release through ryanodine receptor type-2
(RyR2) has been implicated in atrial fibrillation (AF) promotion. Diastolic sarcoplasmic …

Inflammatory cell infiltration in left atrial appendageal tissues of patients with atrial fibrillation and sinus rhythm

C Hohmann, R Pfister, M Mollenhauer, C Adler… - Scientific Reports, 2020 - nature.com
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia in clinical practice
and is known to be associated with significant morbidity and mortality. Previous studies …

Long noncoding RNA TCONS‐00106987 promotes atrial electrical remodelling during atrial fibrillation by sponging miR‐26 to regulate KCNJ2

J Du, Z Li, X Wang, J Li, D Liu, X Wang… - Journal of Cellular …, 2020 - Wiley Online Library
Long noncoding RNAs (lncRNAs) have been suggested to play indispensable roles in
multiple heart diseases. However, the correlations between lncRNAs and atrial fibrillation …

Atrial fibrillation after cardiac surgery: electrophysiological mechanism and outcome

MP Ehrlich, E Osorio-Jaramillo, T Aref, I Coti… - The Annals of Thoracic …, 2020 - Elsevier
Background Postoperative atrial fibrillation (POAF) is common after cardiac surgery and is
associated with an inferior outcome. The high cure rate compared with non-POAF raises …

Proteomic analysis of atrial appendages revealed the pathophysiological changes of atrial fibrillation

B Liu, X Li, C Zhao, Y Wang, M Lv, X Shi, C Han… - Frontiers in …, 2020 - frontiersin.org
Atrial fibrillation (AF), known as the most common arrhythmia in the developed world, affects
1.5–2.0% of the population. Numerous basic studies have been carried out to identify the …

An implantable system for long-term assessment of atrial fibrillation substrate in unanesthetized rats exposed to underlying pathological conditions

H Klapper-Goldstein, M Murninkas, R Gillis, W Mulla… - Scientific Reports, 2020 - nature.com
Atrial fibrillation (AF) is a progressive arrhythmia with underlying mechanisms that are not
fully elucidated, partially due to lack of reliable and affordable animal models. Here, we …

Long non-coding RNAs in atrial fibrillation: pluripotent stem cell-derived cardiomyocytes as a model system

E Bektik, DB Cowan, DZ Wang - International Journal of Molecular …, 2020 - mdpi.com
Atrial fibrillation (AF) is a type of sustained arrhythmia in humans often characterized by
devastating alterations to the cardiac conduction system as well as the structure of the atria …

Noncoding RNAs in atrial fibrillation: current status and prospect

D Zhou, K Yang, J Hu, J Shi, X Hu - Journal of Cardiovascular …, 2020 - journals.lww.com
Atrial fibrillation (AF) is an important cause of cardiovascular morbidity and mortality. Current
therapies for AF are ineffective, mainly due to incomplete understanding of the pathogenesis …