The pig is an omnivorous, monogastric species with many advantages to serve as an animal
model for human diseases. There are very high similarities to humans in anatomy and …

Cystic fibrosis (CF) remains the most common life-shortening hereditary disease in white
populations, with high morbidity and mortality related to chronic airway mucus obstruction …

Pf bacteriophage are temperate phages that infect the bacterium Pseudomonas aeruginosa,
a major cause of chronic lung infections in cystic fibrosis (CF) and other settings. Pf and …

Less than 20% of the protein coding genome is thought to be targetable using small
molecules. mRNA therapies are not limited in the same way since in theory, they can silence …

Cystic fibrosis (CF) is the most common genetic disorder among Caucasians, estimated to
affect more than 70,000 people in the world. Severe and persistent bronchial inflammation …

Rationale: Animal models have been highly informative for understanding the
characteristics, onset, and progression of cystic fibrosis (CF) lung disease. In particular, the …

Cystic fibrosis (CF) lung disease is characterized by an inflammatory response that can lead
to terminal respiratory failure. The cystic fibrosis transmembrane conductance regulator …

Submucosal glands (SMGs) are a prominent structure that lines human cartilaginous
airways. Although it has been assumed that SMGs contribute to respiratory defense, that …

Animal models of cystic fibrosis (CF) are essential for investigating disease mechanisms and
trialing potential therapeutics. This study generated two CF rat models using clustered …

Rationale: In cystic fibrosis the major cause of morbidity and mortality is lung disease
characterized by inflammation and infection. The influence of sphingolipid metabolism is …