[HTML][HTML] Alterations of DNA damage repair in cancer: from mechanisms to applications
M Jiang, K Jia, L Wang, W Li, B Chen… - Annals of …, 2020 - ncbi.nlm.nih.gov
DNA damage repair (DDR) pathways are essential to ensure the accurate transmission of
genetic material. However, different endogenous and exogenous factors challenge genomic …
genetic material. However, different endogenous and exogenous factors challenge genomic …
Targeting DNA-PK in cancer
G Damia - … Research/Fundamental and Molecular Mechanisms of …, 2020 - Elsevier
DNA-dependent protein kinase (DNA-PK) is involved in many cellular pathways. It has a key
role in the cellular response to DNA damage, in the repair of DNA double-strand break (DNA …
role in the cellular response to DNA damage, in the repair of DNA double-strand break (DNA …
The MD Anderson prostate cancer patient-derived xenograft series (MDA PCa PDX) captures the molecular landscape of prostate cancer and facilitates marker-driven …
N Palanisamy, J Yang, PDA Shepherd… - Clinical Cancer …, 2020 - AACR
Purpose: Advances in prostate cancer lag behind other tumor types partly due to the paucity
of models reflecting key milestones in prostate cancer progression. Therefore, we develop …
of models reflecting key milestones in prostate cancer progression. Therefore, we develop …
Phase 1/2 trial of talazoparib in combination with temozolomide in children and adolescents with refractory/recurrent solid tumors including Ewing sarcoma: A …
ES Schafer, RE Rau, SL Berg, X Liu… - Pediatric blood & …, 2020 - Wiley Online Library
Purpose We conducted a phase 1/2 trial of the poly (ADP‐ribose) polymerase 1/2 inhibitor
talazoparib in combination with low‐dose temozolomide (TMZ) to determine the dose …
talazoparib in combination with low‐dose temozolomide (TMZ) to determine the dose …
ETS transcription factors as emerging drug targets in cancer
The ETS family of proteins consists of 28 transcription factors, many of which have been
implicated in development and progression of a variety of cancers. While one family …
implicated in development and progression of a variety of cancers. While one family …
Targetable gene fusions and aberrations in genitourinary oncology
Gene fusions result from either structural chromosomal rearrangement or aberrations
caused by splicing or transcriptional readthrough. The precise and distinctive presence of …
caused by splicing or transcriptional readthrough. The precise and distinctive presence of …
[HTML][HTML] DNA-PK in human malignant disorders: Mechanisms and implications for pharmacological interventions
M Medová, M Medo, L Hovhannisyan… - Pharmacology & …, 2020 - Elsevier
The DNA-PK holoenzyme is a fundamental element of the DNA damage response
machinery (DDR), which is responsible for cellular genomic stability. Consequently, and …
machinery (DDR), which is responsible for cellular genomic stability. Consequently, and …
[HTML][HTML] Molecular mechanisms of docetaxel resistance in prostate cancer
Y Sekino, J Teishima - Cancer Drug Resistance, 2020 - ncbi.nlm.nih.gov
Docetaxel (DTX) chemotherapy offers excellent initial response and confers significant
survival benefit in patients with castration-resistant prostate cancer (CRPC). However, the …
survival benefit in patients with castration-resistant prostate cancer (CRPC). However, the …
[HTML][HTML] DNA damage promotes TMPRSS2-ERG oncoprotein destruction and prostate cancer suppression via signaling converged by GSK3β and WEE1
TMPRSS2-ERG gene fusion occurs in approximately 50% of cases of prostate cancer (PCa),
and the fusion product is a key driver of prostate oncogenesis. However, how to leverage …
and the fusion product is a key driver of prostate oncogenesis. However, how to leverage …
Incorporating Parp-inhibitors in Primary and Recurrent Ovarian Cancer: A Meta-analysis of 12 phase II/III randomized controlled trials
Background The second decade of 2000s is witnessing a new ovarian cancer (OC)
paradigm shift thanks to the results recently obtained by a new class of targeted agents: the …
paradigm shift thanks to the results recently obtained by a new class of targeted agents: the …