Cytotoxic T cell immunity in response to chronic infections and tumours is maintained by a
specialized population of CD8+ T cells that exhibit hallmarks of both exhausted and memory …

Central memory CD8+ T cells (Tcm) control systemic secondary infections and can protect
from chronic infection and cancer as a result of their stem-cell-like capacity to expand …

Abstract Human immunodeficiency virus 1 (HIV-1) infection is associated with heightened
inflammation and excess risk of cardiovascular disease, cancer and other complications …

Chronic cytomegalovirus (CMV) infection leads to long-term maintenance of extraordinarily
large CMV-specific T cell populations. The magnitude of this so-called 'memory inflation'is …

Summary T cell factor 1 (Tcf1) promotes the central memory CD8+ T (T CM) cell
differentiation and stemness in lymphoid tissues after systemic infections. It remains unclear …

Recent studies support the notion that glycolysis and oxidative phosphorylation are
rheostats in immune cells whose bioenergetics have functional outputs in terms of their …

The dynamics of CD4+ T cell memory development remain to be examined at genome
scale. In malaria-endemic regions, antimalarial chemoprevention protects long after its …

Cytomegalovirus-based vaccine vectors offer interesting opportunities for T cell-based
vaccination purposes as CMV infection induces large numbers of functional effector-like …

Background The repetitive antigen stimulation during chronic infection often leads to the
accumulation of CD8+ CD57+ T cells. These cells express high levels of interferon-γ …

Improving effector activity of antigen specific T cells is a major goal in cancer
immunotherapy. Despite the identification of several effector T cell (TEFF)-driving …