The regulation of energy homeostasis is controlled by the brain and, besides requiring high
amounts of energy, it relies on functional insulin/insulin‐like growth factor (IGF)‐1 signalling …

Subsequent to the discovery of insulin by Banting and Best in the Department of Physiology
at the University of Toronto 100 years ago, the field of insulin signalling and action has …

Obesity and metabolic syndrome are associated with cognitive decline and dementia.
Palmitic acid (PA) is increased in the cerebrospinal fluid of obese patients with cognitive …

Saturated fatty acids such as palmitic acid promote inflammation and insulin resistance in
peripheral tissues, contrasting with the protective action of polyunsaturated fatty acids such …

Aims: Selenoproteins are an essential class of proteins involved in redox signaling and
energy metabolism. However, the functions of many selenoproteins are not clearly …

Palmitic acid (PA) is a saturated fatty acid whose high consumption has been largely
associated with the development of different metabolic alterations, such as insulin …

Neuroinflammation has been implicated in the pathogenesis of neurodegeneration and is
now accepted as a common molecular feature underpinning neuronal damage and death …

Phytoestrogens can control high‐fat diet‐induced hypothalamic inflammation that is
associated with severe consequences, including obesity, type 2 diabetes, cardiovascular …

Background Recent studies have considered the obesity-related lipid environment as the
potential cause for M1 macrophage polarization in type 2 diabetes. However, the specific …

Elevated level of palmitic acid (PA), a long-chain saturated fatty acid (SFA), is lipotoxic to
many different types of cells including Neuro-2a (N2a) neuroblastoma cells. CD36 is a …