Reactive oxygen species (ROS) are important in regulating normal cellular processes
whereas deregulated ROS leads to the development of a diseased state in humans …

Pancreatic cancer is a lethal disease with limited opportunity for resectable surgery as the
first choice for cure due to its late diagnosis and early metastasis. The desmoplastic stroma …

Cancer bioenergetics fuel processes necessary to maintain viability and growth under stress
conditions. We hypothesized that cancer metabolism supports the repair of radiation …

The subpopulation of cancer stem cells (CSCs) within tumor bulk are known for tumor
recurrence and metastasis. CSCs show intrinsic resistance to conventional therapies and …

To meet the anabolic demands of the proliferative potential of tumor cells, malignant cells
tend to rewire their metabolic pathways. Although different types of malignant cells share this …

Metabolic activities are altered in cancer cells compared with those in normal cells, and the
cancer-specific pathway becomes a potential therapeutic target. Higher cellular glucose …

Although, numerous in vitro studies showed that cancer cells are killed after exposure to
pharmacological doses of ascorbic acid (AA), significant clinical data proving the efficacy of …

寒武纪生命大爆发是一次由于环境氧浓度改变而导致的重大生命演化事件。
对氧气的利用是高等生命赖以生存的本能， 并因此进化出了复杂的调节系统来应对环境中氧气 …

Pancreatic ductal adenocarcinoma (PDAC), commonly referred to as pancreatic cancer, is
associated with profound chemoresistance, resulting in an extremely poor prognosis with a …

Cancer is a major healthcare burden worldwide. Despite the high heterogeneity of
malignant diseases, several characteristics, described as cancer hallmarks, are common …