Background: Drug overdose or chemical exposures are the main causes of acute liver injury
(ALI). Severe liver injury can develop into liver failure that is an important cause of liver …

Disruptions in the human gut microbiome have been associated with a cycle of hepatocyte
injury and regeneration characteristic of chronic liver disease. Evidence suggests that the …

Nonalcoholic fatty liver disease (NAFLD) is a global health-care problem with limited
therapeutic options. To obtain a cellular resolution of pathogenesis, 82,168 single-cell …

Primary sclerosing cholangitis (PSC) is an immune-related cholangiopathy characterized by
biliary inflammation, cholestasis, and multifocal bile duct strictures. It is associated with high …

Inflammatory bowel disease (IBD), a global disease threatening human health, is commonly
accompanied by secondary liver damage (SLD) mediated by the gut‐liver axis. Oxidative …

Itaconate is a promising new candidate for anti-inflammatory and metabolic reprogramming,
and 4-octyl itaconate (OI) is a cell-permeable itaconate derivative. To investigate the effect of …

In chronic liver disease, the causative factor is important; however, recently, the intestinal
microbiome has been associated with the progression of chronic liver disease and the …

Patients with primary sclerosing cholangitis (PSC) constitute 5 to 15% of patients listed for
liver transplantation worldwide. Although post-transplant outcomes are favorable, recurrent …

Background: The exact pathogenesis of psoriasis is complex, and scholars use the intestinal
mucosal immunity as an entry point to analyze the important role of the intestine in the …

目的: 评价活化自体淋巴细胞过继性免疫治疗(adoptive immunotherapy, AIT)
是否有助于改善原发性肝细胞癌的临床疗效. 方法: 选取2016 年8 月至2018 年12 …