The emerging roles of long noncoding RNAs as hallmarks of lung cancer

J Jiang, Y Lu, F Zhang, J Huang, X Ren… - Frontiers in oncology, 2021 - frontiersin.org
Noncoding ribonucleic acids (ncRNAs) are closely associated with tumor initiation, growth,
and progress in lung cancer. Long ncRNAs (lncRNAs), as one of the three subclasses of …

New insights into the importance of long non-coding RNAs in lung cancer: future clinical approaches

H Ghahramani Almanghadim, S Ghorbian… - DNA and cell …, 2021 - liebertpub.com
In mammals, a large part of the gene expression products come from the non-coding
ribonucleotide sequences of the protein. These short and long sequences are within the …

Myristoylation-mediated phase separation of EZH2 compartmentalizes STAT3 to promote lung cancer growth

J Zhang, Y Zeng, Y Xing, X Li, L Zhou, L Hu, YE Chin… - Cancer Letters, 2021 - Elsevier
N-myristoylation is a crucial signaling and pathogenic modification process that confers
hydrophobicity to cytosolic proteins. Although different large-scale approaches have been …

[HTML][HTML] SP1-upregulated LBX2-AS1 promotes the progression of glioma by targeting the miR-491-5p/LIF axis

W Li, I Soufiany, X Lyu, C Lu, Y Wei, Z Shi… - Journal of …, 2021 - ncbi.nlm.nih.gov
Background: Mounting evidences have shown the importance of lncRNAs in carcinogenesis
and cancer progression. LBX2-AS1 is identified as an oncogenic lncRNA that is abnormally …

NF-κB-activated SPRY4-IT1 promotes cancer cell metastasis by downregulating TCEB1 mRNA via Staufen1-mediated mRNA decay

L Zhao, L Jiang, M Zhang, Q Zhang, Q Guan, Y Li… - Oncogene, 2021 - nature.com
Previous study demonstrated that most long non-coding RNAs (lncRNAs) function as
competing endogenous RNAs or molecular sponges to negatively modulate miRNA and …

RETRACTED ARTICLE: The long noncoding RNA CRYBG3 induces aneuploidy by interfering with spindle assembly checkpoint via direct binding with Bub3

Z Guo, Y Dai, W Hu, Y Zhang, Z Cao, W Pei, N Liu… - Oncogene, 2021 - nature.com
Aneuploidy is a hallmark of genomic instability that leads to tumor initiation, progression,
and metastasis. CDC20, Bub1, and Bub3 form the mitosis checkpoint complex (MCC) that …

MCA-NET: multi-feature coding and attention convolutional neural network for predicting lncRNA-disease association

Y Zhang, F Ye, X Gao - IEEE/ACM Transactions on …, 2021 - ieeexplore.ieee.org
With the advent of the era of big data, it is troublesome to accurately predict the associations
between lncRNAs and diseases based on traditional biological experiments due to its time …

[HTML][HTML] Emerging roles of LncRNAs in the EZH2-regulated oncogenic network

A Hao, Y Wang, DB Stovall, Y Wang… - International Journal of …, 2021 - ncbi.nlm.nih.gov
Cancer is a life-threatening disease, but cancer therapies based on epigenetic mechanisms
have made great progress. Enhancer of zeste homolog 2 (EZH2) is the key catalytic …

GATA1-induced upregulation of LINC01503 promotes carboplatin resistance in ovarian carcinoma by upregulating PD-L1 via sponging miR-766-5p

Y Li, Y Zhai, Y Chen - Journal of Ovarian Research, 2021 - Springer
Abstract Background Ovarian Carcinoma (OCa) is a high-mortality malignancy derived from
female reproductive system. Increasing evidence has identified long non-coding RNAs …

Lateral flow assay-based detection of long non-coding RNAs: A point-of-care platform for cancer diagnosis

S Ranjan, S Jain, A Bhargava, R Shandilya… - … of Pharmaceutical and …, 2021 - Elsevier
Lateral flow assay (LFA) is a flexible, simple, low-costpoint-of-care platform for rapid
detection of disease-specific biomarkers. Importantly, the ability of the assay to capture the …