Advances in long-acting injectables, implants, and vaginal rings for contraception and HIV prevention

SA Krovi, LM Johnson, E Luecke, SL Achilles… - Advanced drug delivery …, 2021 - Elsevier
Worldwide, women face compounding reproductive health risks, including human
immunodeficiency virus (HIV), sexually-transmitted infections (STIs), and unintended …

Transformation of tenofovir into stable ProTide nanocrystals with long-acting pharmacokinetic profiles

DA Cobb, N Smith, S Deodhar, AN Bade… - Nature …, 2021 - nature.com
Abstract Treatment and prevention of human immunodeficiency virus type one (HIV-1)
infection was transformed through widespread use of antiretroviral therapy (ART). However …

Aqueous core microcapsules as potential long-acting release systems for hydrophilic drugs

RM Abuhamdan, BH Al-Anati, Y Al Thaher… - International Journal of …, 2021 - Elsevier
We have previously optimized the internal phase separation process to give rise to aqueous
core microcapsules with polymeric shells composed of poly (lactide-co-glycolide)(PLGA) or …

Nanomedicines for the treatment of infectious diseases: Formulation, delivery and commercialization aspects

A Dube, B Semete-Makokotlela… - Green Synthesis in …, 2021 - taylorfrancis.com
Common modes of transmission of an infectious disease include coughing, sneezing and
exchange of body fluids. In a broad sense, what differentiates this definition of an infectious …

[HTML][HTML] Europium sulfide nanoprobes predict antiretroviral drug delivery into HIV-1 cell and tissue reservoirs

J Herskovitz, M Hasan, J Machhi, I Mukadam… - …, 2021 - ncbi.nlm.nih.gov
Background: Delivery of long-acting nanoformulated antiretroviral drugs (ARVs) to human
immunodeficiency virus type one cell and tissue reservoirs underlies next generation …

Development of Once-A-Year Injectable Formulation of Cabotegravir for Prevention and Treatment of HIV Infection

TA Kulkarni - 2021 - digitalcommons.unmc.edu
Long-acting cabotegravir (CAB) extends antiretroviral drug (ARV) dosing to monthly for
maintenance of human immunodeficiency virus type one (HIV-1) suppression and to every …

Development of Long-Acting Antiviral Drug Nanoformulations

D Cobb - 2021 - digitalcommons.unmc.edu
Antiretroviral therapy (ART) has improved the quality and duration of life for people living
with human immunodeficiency virus (HIV) infection. However, opportunities to improve its …

HIV-1 mimicking lipid-coated polymer nanoparticles: fundamentals and applications

B Eshaghi - 2021 - search.proquest.com
Despite tremendous improvement in the development of antiretroviral therapy (ART) for
treatment of human immunodeficiency virus‐1 (HIV‐1), a cure is currently missing. One of …