[HTML][HTML] Relapsed medulloblastoma in pre-irradiated patients: current practice for diagnostics and treatment

RM Hill, SLA Plasschaert, B Timmermann, C Dufour… - Cancers, 2021 - mdpi.com
Simple Summary Medulloblastoma is the commonest malignant brain tumour of childhood.
Disease relapse following maximal multi-modal therapy including upfront craniospinal …

Temozolomide with irinotecan versus temozolomide, irinotecan plus bevacizumab for recurrent medulloblastoma of childhood: Report of a COG randomized Phase II …

AS Levy, M Krailo, S Chi, D Villaluna… - Pediatric blood & …, 2021 - Wiley Online Library
Background: Approximately 30% of children with medulloblastoma (MB) experience
recurrence, which is usually incurable. This study compared the overall survival (OS) of …

[HTML][HTML] Exploring genetic alterations in circulating tumor DNA from cerebrospinal fluid of pediatric medulloblastoma

Y Sun, M Li, S Ren, Y Liu, J Zhang, S Li, W Gao… - Scientific reports, 2021 - nature.com
Medulloblastoma (MB) is the most common type of brain malignancy in children. Molecular
profiling has become an important component to select patients for therapeutic approaches …

MEVITEM—A phase I/II trial of vismodegib+ temozolomide vs temozolomide in patients with recurrent/refractory medulloblastoma with Sonic Hedgehog pathway …

D Frappaz, M Barritault, L Montané… - Neuro …, 2021 - academic.oup.com
Abstract Background Vismodegib specifically inhibits Sonic Hedgehog (SHH). We report
results of a phase I/II evaluating vismodegib+ temozolomide (TMZ) in …

Application of genome-wide DNA methylation analysis to differentiate a case of radiation-induced glioblastoma from late-relapsed medulloblastoma

T Hiraki, K Fukuoka, M Mori, Y Arakawa… - … of Neuropathology & …, 2021 - academic.oup.com
Recurrent medulloblastoma can be difficult to diagnose with conventional diagnostic
methods because other lesions mimic tumor relapse, particularly at later stages. We report 2 …

Pediatric gastrointestinal stromal tumors and neuroendocrine tumors: advances in surgical management

H Garnier, C Loo, P Czauderna… - Surgical Oncology …, 2021 - surgonc.theclinics.com
Gastrointestinal stromal tumors (GIST) and neuroendocrine tumors (NET) are extremely rare
within the pediatric population. Although it is possible for GIST and a Department of Surgery …

[HTML][HTML] Medulloblastoma in adults–reviewing the literature from a surgeon's point of view

T Eibl, A Hammer, E Yakubov, C Blechschmidt… - Aging (Albany …, 2021 - ncbi.nlm.nih.gov
Medulloblastoma is a common primary brain tumor in children but it is a rare cancer in adult
patients. We reviewed the literature, searching PubMed for articles on this rare tumor entity …

[HTML][HTML] Bevacizumab, irinotecan, and temozolomide with re-irradiation in adult recurrent medulloblastoma: A first case report

T Yamauchi, R Kitai, H Arai, M Kidoguchi… - Interdisciplinary …, 2021 - Elsevier
Medulloblastoma in adults is very rare, and there is no effective therapy for its initial
appearance or recurrence. We present a case of a 40-year-old male with recurrent …