[HTML][HTML] Polyphenols from food by-products: An alternative or complementary therapy to IBD conventional treatments

AP da Fonseca Machado, MV Geraldi… - Food research …, 2021 - Elsevier
Inflammatory bowel diseases (IBD) are illnesses characterized by chronic intestinal
inflammation and microbial dysbiosis that have emerged as a public health challenge …

[HTML][HTML] Ozone-induced oxidative stress, neutrophilic airway inflammation, and glucocorticoid resistance in asthma

C Enweasor, CH Flayer, A Haczku - Frontiers in Immunology, 2021 - frontiersin.org
Despite recent advances in using biologicals that target Th2 pathways, glucocorticoids form
the mainstay of asthma treatment. Asthma morbidity and mortality remain high due to the …

Current perspective on eicosanoids in asthma and allergic diseases: EAACI Task Force consensus report, part I

M Sokolowska, GE Rovati, Z Diamant, E Untersmayr… - Allergy, 2021 - Wiley Online Library
Eicosanoids are biologically active lipid mediators, comprising prostaglandins, leukotrienes,
thromboxanes, and lipoxins, involved in several pathophysiological processes relevant to …

Nuclear receptors in podocyte biology and glomerular disease

S Agrawal, JC He, PL Tharaux - Nature Reviews Nephrology, 2021 - nature.com
Nuclear receptors have a broad spectrum of biological functions in normal physiology and in
the pathology of various diseases, including glomerular disease. The primary therapies for …

[HTML][HTML] Pharmacological rationale for targeting IL-17 in asthma

SF Rahmawati, M Te Velde, HAM Kerstjens… - Frontiers in …, 2021 - frontiersin.org
Asthma is a respiratory disease that currently affects around 300 million people worldwide
and is defined by coughing, shortness of breath, wheezing, mucus overproduction, chest …

[HTML][HTML] Mifepristone (RU486) inhibits dietary lipid digestion by antagonizing the role of glucocorticoid receptor on lipase transcription

P Ma, Y Zhang, Q Liang, Y Yin, S Wang, R Han, C Huo… - Iscience, 2021 - cell.com
Lipid digestion and absorption are tightly regulated to cope with metabolic demands among
tissues. How these processes are coordinated is not well characterized. Here, we found that …

The role of systemic corticosteroids in severe asthma and new evidence in their management and tapering

F Menzella, G Ghidoni, M Fontana… - Expert review of …, 2021 - Taylor & Francis
Introduction Based on the latest literature evidence, between 30% and 60% of adults with
severe refractory asthma (SRA) are systemic corticosteroid (SCS) dependent. There are …

SIRT1 single-nucleotide polymorphisms are associated with corticosteroid sensitivity in primary immune thrombocytopenia patients

S Wang, X Zhang, S Leng, Y Zhang, J Li, J Peng… - Annals of …, 2021 - Springer
Background Primary immune thrombocytopenia (ITP) is an autoimmune disorder
characterized by decreased platelet count. While corticosteroids are a useful first-line …

[HTML][HTML] Nuclear receptors in asthma: empowering classical molecules against a contemporary ailment

D Tiwari, P Gupta - Frontiers in immunology, 2021 - frontiersin.org
The escalation in living standards and adoption of 'Western lifestyle'has an allied effect on
the increased allergy and asthma burden in both developed and developing countries …

Association of glucocorticoid receptor gene NR3C1 (Tth111I, Bcli) polymorphisms with asthma children in Iraq

HM Al-Shami, SJ Al-Awadi… - Annals of the Romanian …, 2021 - annalsofrscb.ro
Glucocorticoids in-general are considered the most powerful and efficient treatment for
asthma. The following investigation was aimed to study the effect of the glucocorticoid …