Vascular smooth muscle cells in aortic aneurysm: from genetics to mechanisms

H Lu, W Du, L Ren, MH Hamblin… - Journal of the …, 2021 - Am Heart Assoc
Aortic aneurysm, including thoracic aortic aneurysm and abdominal aortic aneurysm, is the
second most prevalent aortic disease following atherosclerosis, representing the ninth …

[HTML][HTML] Senescence and senolytics in cardiovascular disease: Promise and potential pitfalls

WA Owens, A Walaszczyk, I Spyridopoulos… - Mechanisms of Ageing …, 2021 - Elsevier
Ageing is the biggest risk factor for impaired cardiovascular health, with cardiovascular
disease being the cause of death in 40% of individuals over 65 years old. Ageing is …

TREM-1 orchestrates angiotensin II–induced monocyte trafficking and promotes experimental abdominal aortic aneurysm

M Vandestienne, Y Zhang, I Santos-Zas… - The Journal of …, 2021 - Am Soc Clin Investig
The triggering receptor expressed on myeloid cells 1 (TREM-1) drives inflammatory
responses in several cardiovascular diseases but its role in abdominal aortic aneurysm …

Relationship between autophagy and metabolic syndrome characteristics in the pathogenesis of atherosclerosis

J Xu, M Kitada, Y Ogura, D Koya - Frontiers in cell and developmental …, 2021 - frontiersin.org
Atherosclerosis is the main cause of mortality in metabolic-related diseases, including
cardiovascular disease and type 2 diabetes (T2DM). Atherosclerosis is characterized by …

[HTML][HTML] MKL1 cooperates with p38MAPK to promote vascular senescence, inflammation, and abdominal aortic aneurysm

P Gao, P Gao, J Zhao, S Shan, W Luo, OJ Slivano… - Redox biology, 2021 - Elsevier
Abdominal aortic aneurysm (AAA) is a catastrophic disease with little effective therapy.
Myocardin related transcription factor A (MRTFA, MKL1) is a multifaceted transcription factor …

Immune-based therapies in cardiovascular and metabolic diseases: past, present and future

AJ Murphy, MA Febbraio - Nature Reviews Immunology, 2021 - nature.com
Cardiometabolic disorders were originally thought to be driven primarily by changes in lipid
metabolism that cause the accumulation of lipids in organs, thereby impairing their function …

[HTML][HTML] Translating mouse models of abdominal aortic aneurysm to the translational needs of vascular surgery

A Busch, S Bleichert, N Ibrahim, M Wortmann… - JVS-vascular …, 2021 - Elsevier
Introduction Abdominal aortic aneurysm (AAA) is a condition that has considerable
socioeconomic impact and an eventual rupture is associated with high mortality and …

Erythropoietin promotes abdominal aortic aneurysms in mice through angiogenesis and inflammatory infiltration

M Zhang, W Sui, C Cheng, F Xue, Z Tian… - Science translational …, 2021 - science.org
Abdominal aortic aneurysm (AAA) is a potentially fatal vascular disease, but the underlying
mechanisms remain unknown. Here, we tested the hypothesis that erythropoietin (EPO) may …

Transforming growth factor-β and the renin-angiotensin system in syndromic thoracic aortic aneurysms: implications for treatment

DCH van Dorst, NP de Wagenaar… - … Drugs and Therapy, 2021 - Springer
Thoracic aortic aneurysms (TAAs) are permanent pathological dilatations of the thoracic
aorta, which can lead to life-threatening complications, such as aortic dissection and rupture …

Cardiac pressure overload decreases ETV1 expression in the left atrium, contributing to atrial electrical and structural remodeling

N Yamaguchi, J Xiao, D Narke, D Shaheen, X Lin… - Circulation, 2021 - Am Heart Assoc
Background: Elevated intracardiac pressure attributable to heart failure induces electrical
and structural remodeling in the left atrium (LA) that begets atrial myopathy and arrhythmias …