Myocardial tissue characterization in heart failure with preserved ejection fraction: from histopathology and cardiac magnetic resonance findings to therapeutic targets
P Severino, A D'Amato, S Prosperi, F Fanisio… - International Journal of …, 2021 - mdpi.com
Heart failure with preserved ejection fraction (HFpEF) is a complex clinical syndrome
responsible for high mortality and morbidity rates. It has an ever growing social and …
responsible for high mortality and morbidity rates. It has an ever growing social and …
Sodium-glucose cotransporter 2 inhibitors and heart failure: The best timing for the right patient
P Severino, A D'Amato, S Prosperi, B Costi… - Heart Failure …, 2021 - Springer
Sodium-glucose cotransporter 2 inhibitors (SGLT2i), initially born as anti-diabetic drugs,
have shown many beneficial effects on the cardiovascular system, in particular against heart …
have shown many beneficial effects on the cardiovascular system, in particular against heart …
Neurohormonal activation induces intracellular iron deficiency and mitochondrial dysfunction in cardiac cells
M Tajes, C Díez-López, C Enjuanes, P Moliner… - Cell & Bioscience, 2021 - Springer
Background Iron deficiency (ID) is common in patients with heart failure (HF) and is
associated with poor outcomes, yet its role in the pathophysiology of HF is not well-defined …
associated with poor outcomes, yet its role in the pathophysiology of HF is not well-defined …
Potential role of eNOS genetic variants in ischemic heart disease susceptibility and clinical presentation
P Severino, A D'Amato, S Prosperi… - Journal of …, 2021 - mdpi.com
Background: IHD is determined by an inadequate coronary blood supply to the myocardium,
and endothelial dysfunction may represent one of the main pathophysiological mechanisms …
and endothelial dysfunction may represent one of the main pathophysiological mechanisms …
[HTML][HTML] Functional and molecular effects of TNF-α on human iPSC-derived cardiomyocytes
Proinflammatory molecule tumor necrosis factor alpha (TNF-α) is predominantly elevated in
cytokine storm as well as worsening cardiac function. Here we model the molecular and …
cytokine storm as well as worsening cardiac function. Here we model the molecular and …
Protective mechanism of demethylase fat mass and obesity‐associated protein in energy metabolism disorder of hypoxia–reoxygenation‐induced cardiomyocytes
W Deng, Q Jin, L Li - Experimental Physiology, 2021 - Wiley Online Library
New Findings What is the central question of this study? What is the effect of fat mass and
obesity‐associated protein (FTO) on energy metabolism in hypoxia–reoxygenation (H/R) …
obesity‐associated protein (FTO) on energy metabolism in hypoxia–reoxygenation (H/R) …
Serum complement C1q activity is associated with obstructive coronary artery disease
S Guo, X Mao, X Li, H Ouyang, Y Gao… - Frontiers in …, 2021 - frontiersin.org
Background: Complement C1q plays a dual role in the atherosclerosis. Previous studies
showed inconsistent results about the association of serum C1q levels and coronary artery …
showed inconsistent results about the association of serum C1q levels and coronary artery …
The effect of magnesium on reperfusion arrhythmias in STEMI patients, treated with PPCI. A systematic review with a meta-analysis and trial sequential analysis
Aims: The restoration of coronary circulation plays a crucial role in treating ST-segment
elevation myocardial infarction (STEMI), however successful reperfusion with primary …
elevation myocardial infarction (STEMI), however successful reperfusion with primary …
[PDF][PDF] The effect of dexmedetomidine on myocardial ischemia/reperfusion injury in patients undergoing cardiac surgery with cardiopulmonary bypass: a meta-analysis …
GR Zhang, CM Peng, ZZ Liu… - European Review for …, 2021 - europeanreview.org
OBJECTIVE: The purpose of this study was to evaluate the effect of dexmedetomidine
administration on myocardial ischemia/reperfusion (I/R) injury in patients undergoing …
administration on myocardial ischemia/reperfusion (I/R) injury in patients undergoing …
Deficiency in Neuroserpin Exacerbates CoCl2 Induced Hypoxic Injury in the Zebrafish Model by Increased Oxidative Stress
S Han, D Zhang, Q Dong, X Wang… - Frontiers in …, 2021 - frontiersin.org
Protective strategy against hypoxic-ischemic (H/I) induced injury has been intensively
discussed. Neuroserpin, an inhibitor for tissue plasminogen activator (tPA), has been proved …
discussed. Neuroserpin, an inhibitor for tissue plasminogen activator (tPA), has been proved …