Heart failure with preserved ejection fraction (HFpEF) is a complex clinical syndrome
responsible for high mortality and morbidity rates. It has an ever growing social and …

Sodium-glucose cotransporter 2 inhibitors (SGLT2i), initially born as anti-diabetic drugs,
have shown many beneficial effects on the cardiovascular system, in particular against heart …

Background Iron deficiency (ID) is common in patients with heart failure (HF) and is
associated with poor outcomes, yet its role in the pathophysiology of HF is not well-defined …

Background: IHD is determined by an inadequate coronary blood supply to the myocardium,
and endothelial dysfunction may represent one of the main pathophysiological mechanisms …

Proinflammatory molecule tumor necrosis factor alpha (TNF-α) is predominantly elevated in
cytokine storm as well as worsening cardiac function. Here we model the molecular and …

New Findings What is the central question of this study? What is the effect of fat mass and
obesity‐associated protein (FTO) on energy metabolism in hypoxia–reoxygenation (H/R) …

Background: Complement C1q plays a dual role in the atherosclerosis. Previous studies
showed inconsistent results about the association of serum C1q levels and coronary artery …

Aims: The restoration of coronary circulation plays a crucial role in treating ST-segment
elevation myocardial infarction (STEMI), however successful reperfusion with primary …

OBJECTIVE: The purpose of this study was to evaluate the effect of dexmedetomidine
administration on myocardial ischemia/reperfusion (I/R) injury in patients undergoing …

Protective strategy against hypoxic-ischemic (H/I) induced injury has been intensively
discussed. Neuroserpin, an inhibitor for tissue plasminogen activator (tPA), has been proved …