Cytoplasmic aggregation of TAR DNA-binding protein 43 (TDP43; also known as TARDBP
or TDP-43) is a key pathological feature of several neurodegenerative diseases, including …

The hexanucleotide repeat expansion (HRE) in the C9ORF72 gene is the main cause of two
tightly linked neurodegenerative diseases, amyotrophic lateral sclerosis (ALS) and …

Axonal dysfunction is a common phenotype in neurodegenerative disorders, including in
amyotrophic lateral sclerosis (ALS), where the key pathological cell-type, the motor neuron …

The most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal
dementia (FTD) is a hexanucleotide expansion in the chromosome 9 open reading frame 72 …

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are severe
neurodegenerative disorders that belong to a common disease spectrum. The molecular …

Neurodegenerative proteinopathies are characterized by progressive cell loss that is
preceded by the mislocalization and aberrant accumulation of proteins prone to …

The most frequent genetic cause of amyotrophic lateral sclerosis and frontotemporal
dementia is a G4C2 repeat expansion in the C9orf72 gene. This expansion gives rise to …

Since the discovery of the C9orf72 repeat expansion mutation as causative for chromosome
9-linked amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) in 2011, a …

There is ample evidence that nucleocytoplasmic-transport deficits could play an important
role in the pathology of amyotrophic lateral sclerosis (ALS). However, the currently available …

Background Female reproductive behaviors and physiology change profoundly after mating.
The control of pregnancy-associated changes in physiology and behaviors are largely hard …