Antidepressants' effects on testosterone and estrogens: What do we know?

P Pavlidi, N Kokras, C Dalla - European journal of pharmacology, 2021 - Elsevier
Various antidepressants are commonly used to treat depression and anxiety disorders, and
sex differences have been identified in their efficacy and side effects. Steroids, such as …

Application of the comet assay for the evaluation of DNA damage in mature sperm

G Gajski, S Ravlić, R Godschalk, A Collins… - … Research/Reviews in …, 2021 - Elsevier
DNA integrity is considered an important parameter of semen quality and is of significant
value as a predictor of male fertility. Currently, there are several methods that can assess …

[HTML][HTML] Olanzapine induced reproductive toxicity in male rats

CM Ardıç, S Ilgın, M Baysal, AB Karaduman, V Kılıç… - Scientific Reports, 2021 - nature.com
Although it is reported that olanzapine (OLZ), which is an atypical antipsychotic drug, causes
sexual dysfunction in men, it is noteworthy that there is not any study evaluating the toxic …

The antidepressant Sertraline inhibits CatSper Ca2+ channels in human sperm

R Rahban, A Rehfeld, C Schiffer, C Brenker… - Human …, 2021 - academic.oup.com
STUDY QUESTION Do selective serotonin reuptake inhibitor (SSRI) antidepressants affect
the function of human sperm? SUMMARY ANSWER The SSRI antidepressant Sertraline (eg …

Transgenerational effects of BDE-209 on male reproduction in F3 offspring rats

PC Hsu, ZK Li, CS Lai, LH Tseng, CW Lee, FJ Cheng… - Chemosphere, 2021 - Elsevier
Abstract Decabromodiphenyl ether (BDE-209), a congener of polybrominated diphenyl
ethers, is a commonly used brominated flame retardant and a known endocrine disrupting …

[HTML][HTML] Exposure of pregnant rats to stress and/or sertraline: Side effects on maternal health and neurobehavioral development of male offspring

AFQ Lozano, MS Moura, BM Tavares, WDG Kempinas - Life Sciences, 2021 - Elsevier
Aims Sertraline (SE) is one of the most prescribed medications for treating gestational
depression, anxiety and stress. However, little is known about its effects on nervous-system …

[HTML][HTML] Molecular consequences of depression treatment: A potential in vitro mechanism for antidepressants-induced reprotoxic side effects

P Sołek, J Mytych, A Tabęcka-Łonczyńska… - International journal of …, 2021 - mdpi.com
The incidence of depression among humans is growing worldwide, and so is the use of
antidepressants. However, our fundamental understanding regarding the mechanisms by …

The effect of Dolichandrone serrulata (wall. ex DC.) Seem. flower extract containing antioxidant capacity and terpenoids on the male reproductive system

C Chaimontri, S Arun, T Sawatpanich… - Andrologia, 2021 - Wiley Online Library
Although the fruit extract of Dolichandrone genus was shown to inhibit spermatogenesis, the
reproductive toxicity of Dolichandrone serrulata flowers (DSFs) is not documented. Recent …

Risperidone induced reproductive toxicity in male rats targeting leydig cells and hypothalamic–pituitary–gonadal axis by inducing oxidative stress

G Görmüş, S Ilgın, M Baysal, AB Karaduman… - Andrologia, 2021 - Wiley Online Library
Risperidone (RIS), a commonly used drug during a lifetime for the treatment of
schizophrenia, causes some adverse effects in the male reproductive system; however …

A systematic review on the genotoxic effects of selective serotonin reuptake inhibitors

M Ahmadimanesh, MR Abbaszadegan… - Reviews on New Drug …, 2021 - Springer
Depression is a mental disorder and a major public health concern affecting millions of
people worldwide. It is a common disorder that has been associated with several medical …