Interconnections between circadian clocks and metabolism
Circadian rhythms evolved through adaptation to daily light/dark changes in the
environment; they are believed to be regulated by the core circadian clock interlocking …
environment; they are believed to be regulated by the core circadian clock interlocking …
Circadian rhythms of the hypothalamus: from function to physiology
R Van Drunen, K Eckel-Mahan - Clocks & sleep, 2021 - mdpi.com
The nearly ubiquitous expression of endogenous 24 h oscillations known as circadian
rhythms regulate the timing of physiological functions in the body. These intrinsic rhythms …
rhythms regulate the timing of physiological functions in the body. These intrinsic rhythms …
Molecular mechanism of the repressive phase of the mammalian circadian clock
The mammalian circadian clock consists of a transcription–translation feedback loop (TTFL)
composed of CLOCK–BMAL1 transcriptional activators and CRY–PER transcriptional …
composed of CLOCK–BMAL1 transcriptional activators and CRY–PER transcriptional …
Post-transcriptional circadian regulation in macrophages organizes temporally distinct immunometabolic states
EJ Collins, MP Cervantes-Silva, GA Timmons… - Genome …, 2021 - genome.cshlp.org
Our core timekeeping mechanism, the circadian clock, plays a vital role in immunity.
Although the mechanics of circadian control over the immune response is generally …
Although the mechanics of circadian control over the immune response is generally …
[HTML][HTML] The molecular clock and neurodegenerative disease: A stressful time
Circadian rhythm dysfunction occurs in both common and rare neurodegenerative diseases.
This dysfunction manifests as sleep cycle mistiming, alterations in body temperature …
This dysfunction manifests as sleep cycle mistiming, alterations in body temperature …
Clock proteins and training modify exercise capacity in a daytime-dependent manner
Y Adamovich, V Dandavate… - Proceedings of the …, 2021 - National Acad Sciences
Exercise and circadian biology are closely intertwined with physiology and metabolism, yet
the functional interaction between circadian clocks and exercise capacity is only partially …
the functional interaction between circadian clocks and exercise capacity is only partially …
Circadian rhythms in mood disorders
MR Scott, CA McClung - Circadian clock in brain health and disease, 2021 - Springer
Altered behavioral rhythms are a fundamental diagnostic feature of mood disorders. Patients
report worse subjective sleep and objective measures confirm this, implicating a role for …
report worse subjective sleep and objective measures confirm this, implicating a role for …
To Ub or not to Ub: Regulation of circadian clocks by ubiquitination and deubiquitination
SB Srikanta, N Cermakian - Journal of neurochemistry, 2021 - Wiley Online Library
Circadian clocks are internal timing systems that enable organisms to adjust their behavioral
and physiological rhythms to the daily changes of their environment. These clocks generate …
and physiological rhythms to the daily changes of their environment. These clocks generate …
Circadian rhythm disruption and Alzheimer's disease: the dynamics of a vicious cycle
All mammalian cells exhibit circadian rhythm in cellular metabolism and energetics.
Autonomous cellular clocks are modulated by various pathways that are essential for robust …
Autonomous cellular clocks are modulated by various pathways that are essential for robust …
Sleep phenotype of individuals with autism spectrum disorder bearing mutations in the PER2 circadian rhythm gene
N Hoang, RKC Yuen, J Howe, I Drmic… - American Journal of …, 2021 - Wiley Online Library
The Per family of genes functions as a primary circadian rhythm maintenance in the brain.
Mutations in PER2 are associated with familial advanced sleep‐phase syndrome 1 …
Mutations in PER2 are associated with familial advanced sleep‐phase syndrome 1 …