Mining genomes to illuminate the specialized chemistry of life
All organisms produce specialized organic molecules, ranging from small volatile chemicals
to large gene-encoded peptides, that have evolved to provide them with diverse cellular and …
to large gene-encoded peptides, that have evolved to provide them with diverse cellular and …
[HTML][HTML] Advances in decomposing complex metabolite mixtures using substructure-and network-based computational metabolomics approaches
Covering: up to the end of 2020 Recently introduced computational metabolome mining
tools have started to positively impact the chemical and biological interpretation of …
tools have started to positively impact the chemical and biological interpretation of …
NPClassifier: a deep neural network-based structural classification tool for natural products
Computational approaches such as genome and metabolome mining are becoming
essential to natural products (NPs) research. Consequently, a need exists for an automated …
essential to natural products (NPs) research. Consequently, a need exists for an automated …
Metabolomics and genomics in natural products research: complementary tools for targeting new chemical entities
Covering: 2010 to 2021 Organisms in nature have evolved into proficient synthetic chemists,
utilizing specialized enzymatic machinery to biosynthesize an inspiring diversity of …
utilizing specialized enzymatic machinery to biosynthesize an inspiring diversity of …
Machine learning approaches for elucidating the biological effects of natural products
R Zhang, X Li, X Zhang, H Qin, W Xiao - Natural Product Reports, 2021 - pubs.rsc.org
Covering: 2000 to 2020 Machine learning (ML) is an efficient tool for the prediction of
bioactivity and the study of structure–activity relationships. Over the past decade, an …
bioactivity and the study of structure–activity relationships. Over the past decade, an …
[HTML][HTML] Applications of virtual screening in bioprospecting: facts, shifts, and perspectives to explore the chemo-structural diversity of natural products
Natural products are continually explored in the development of new bioactive compounds
with industrial applications, attracting the attention of scientific research efforts due to their …
with industrial applications, attracting the attention of scientific research efforts due to their …
[HTML][HTML] The year 2020 in natural product bioinformatics: an overview of the latest tools and databases
MH Medema - Natural Product Reports, 2021 - pubs.rsc.org
Covering: 2020 Bioinformatic approaches to document and analyse chemical structures,
biosynthetic gene clusters and analytical data play an important role in the study of natural …
biosynthetic gene clusters and analytical data play an important role in the study of natural …
Microbial natural product databases: moving forward in the multi-omics era
Covering: 2010–2020 The digital revolution is driving significant changes in how people
store, distribute, and use information. With the advent of new technologies around linked …
store, distribute, and use information. With the advent of new technologies around linked …
Development of an NMR-based platform for the direct structural annotation of complex natural products mixtures
The development of new “omics” platforms is having a significant impact on the landscape of
natural products discovery. However, despite the advantages that such platforms bring to the …
natural products discovery. However, despite the advantages that such platforms bring to the …
[HTML][HTML] Bacterial pathogens: threat or treat (a review on bioactive natural products from bacterial pathogens)
F Maglangit, Y Yu, H Deng - Natural Product Reports, 2021 - pubs.rsc.org
Covering: up to the second quarter of 2020 Threat or treat? While pathogenic bacteria pose
significant threats, they also represent a huge reservoir of potential pharmaceuticals to treat …
significant threats, they also represent a huge reservoir of potential pharmaceuticals to treat …