The complex link between NAFLD and type 2 diabetes mellitus—mechanisms and treatments

G Targher, KE Corey, CD Byrne… - … reviews Gastroenterology & …, 2021 - nature.com
Nonalcoholic fatty liver disease (NAFLD) has reached epidemic proportions worldwide.
NAFLD and type 2 diabetes mellitus (T2DM) are known to frequently coexist and act …

[HTML][HTML] Nonalcoholic fatty liver disease (NAFLD) from pathogenesis to treatment concepts in humans

K Pafili, M Roden - Molecular Metabolism, 2021 - Elsevier
Background Nonalcoholic fatty liver disease (NAFLD) comprises hepatic alterations with
increased lipid accumulation (steatosis) without or with inflammation (nonalcoholic …

Glucagon-like peptide-1 receptor agonists for treatment of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis: an updated meta-analysis of randomized …

A Mantovani, G Petracca, G Beatrice, A Csermely… - Metabolites, 2021 - mdpi.com
To assess the efficacy of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) for
treatment of nonalcoholic fatty liver disease (NAFLD) or steatohepatitis (NASH), we …

Effects of liraglutide on visceral and ectopic fat in adults with overweight and obesity at high cardiovascular risk: a randomised, double-blind, placebo-controlled …

IJ Neeland, SP Marso, CR Ayers, B Lewis… - The lancet Diabetes & …, 2021 - thelancet.com
Background Visceral and ectopic fat are key drivers of adverse cardiometabolic outcomes in
obesity. We aimed to evaluate the effects of injectable liraglutide 3· 0 mg daily on body fat …

[PDF][PDF] Cancer risk in patients with biopsy‐confirmed nonalcoholic fatty liver disease: a population‐based cohort study

TG Simon, B Roelstraete, R Sharma, H Khalili… - …, 2021 - Wiley Online Library
Background and Aims Recent studies link NAFLD to an increased incidence of HCC and
extrahepatic cancers. However, earlier studies were small or lacked liver histology, which …

[HTML][HTML] Pathophysiological mechanisms and clinical evidence of relationship between Nonalcoholic fatty liver disease (NAFLD) and cardiovascular disease

R Galiero, A Caturano, E Vetrano, A Cesaro… - Reviews in …, 2021 - imrpress.com
Evidence suggests a close connection between Nonalcoholic Fatty Liver Disease (NAFLD)
and increased cardiovascular (CV) risk. Several cross-sectional studies report that NAFLD is …

[PDF][PDF] Group‐2 innate lymphoid cells promote HCC progression through CXCL2‐neutrophil‐induced immunosuppression

X Xu, L Ye, Q Zhang, H Shen, S Li, X Zhang, M Ye… - …, 2021 - Wiley Online Library
Background and Aims Due to their inherent characteristics, the function of group‐2 innate
lymphoid cells (ILC2s) varies in a context‐dependent manner. ILC2s are involved in certain …

Management of Obesity in Cardiovascular Practice: JACC Focus Seminar

JP Despres, AC Carpentier, A Tchernof… - Journal of the American …, 2021 - jacc.org
Obesity contributes to reduced life expectancy because of its link with type 2 diabetes and
cardiovascular disease. Yet, targeting this poorly diagnosed, ill-defined, and …

Can we decrease epicardial and pericardial fat in patients with diabetes?

EM Muzurović, S Vujošević… - Journal of …, 2021 - journals.sagepub.com
Diabetes mellitus (DM) is a chronic and complex metabolic disorder and also an important
cause of cardiovascular (CV) disease (CVD). Patients with type 2 DM (T2DM) and obesity …

Effects of liraglutide on nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus: a systematic review and meta-analysis

T Song, Y Jia, Z Li, F Wang, L Ren, S Chen - Diabetes Therapy, 2021 - Springer
Introduction Nonalcoholic fatty liver disease (NAFLD) is a common comorbidity of type 2
diabetes mellitus (T2DM), and no approved therapies are currently available. A meta …