The liver is a highly dynamic metabolic organ that plays critical roles in plasma protein
synthesis, gluconeogenesis and glycogen storage, cholesterol metabolism and bile acid …

Autophagy is the liver cell energy recycling system regulating a variety of homeostatic
mechanisms. Damaged organelles, lipids and proteins are degraded in the lysosomes and …

Recent reports indicated that mitophagy protects against alcohol-induced liver injury, which
helps remove damaged mitochondria to reduce the accumulation of reactive oxygen species …

Acetaminophen (APAP) overdose can induce liver injury and is the most frequent cause of
acute liver failure in the United States. We investigated the role of p62/SQSTM1 (referred to …

Altered autophagy is implicated in several human cardiovascular diseases. Remote
ischemic conditioning (RIC) is cardioprotective in multiple cardiovascular injury models and …

Autophagy is a “housekeeping” lysosomal degradation process involved in numerous
physiological and pathological processes in all eukaryotic cells. The dysregulation of …

Significance: Fatty liver disease is a major liver disorder in the modern societies.
Comprehensive understanding of the pathophysiology and molecular mechanisms is …

Activation of the mechanistic target of rapamycin (mTOR) pathway is frequently found in
cancer, but mTOR inhibitors have thus far failed to demonstrate significant antiproliferative …

Autophagy removes damaged organelles to inhibit malignant transformation during tumor
initiation. Once a cancer matures, it uses the autophagic pathway as an energy source …

Background Lung adenocarcinoma is one of the most common malignant tumors with high
morbidity and mortality, but the effect of Tumor-associated macrophages (TAMs) on lung …