Structures and functional diversities of ASFV proteins

G Wang, M Xie, W Wu, Z Chen - Viruses, 2021 - mdpi.com
African swine fever virus (ASFV), the causative pathogen of the recent ASF epidemic, is a
highly contagious double-stranded DNA virus. Its genome is in the range of 170~ 193 kbp …

African swine fever virus protein MGF-505-7R promotes virulence and pathogenesis by inhibiting JAK1-and JAK2-mediated signaling

D Li, J Zhang, W Yang, P Li, Y Ru, W Kang, LL Li… - Journal of Biological …, 2021 - ASBMB
African swine fever virus (ASFV) is a large DNA virus that is highly contagious and
pathogenic in domestic pigs with a mortality rate up to 100%. However, how ASFV …

Genome editing strategies to protect livestock from viral infections

JH Söllner, TC Mettenleiter, B Petersen - Viruses, 2021 - mdpi.com
The livestock industry is constantly threatened by viral disease outbreaks, including
infections with zoonotic potential. While preventive vaccination is frequently applied, disease …

African swine fever virus induces STAT1 and STAT2 degradation to counteract IFN-I signaling

E Riera, D Pérez-Núñez, R García-Belmonte… - Frontiers in …, 2021 - frontiersin.org
African swine fever virus (ASFV) causes a serious disease in domestic pigs and wild boars
and is currently expanding worldwide. No safe and efficacious vaccines against ASFV are …

African swine fever virus CD2v protein induces β-interferon expression and apoptosis in swine peripheral blood mononuclear cells

S Chaulagain, GA Delhon, S Khatiwada, DL Rock - Viruses, 2021 - mdpi.com
African swine fever (ASF) is a hemorrhagic disease of swine characterized by massive
lymphocyte depletion in lymphoid tissues due to the apoptosis of B and T cells, a process …

Novel function of African Swine Fever Virus pE66L in inhibition of host translation by the PKR/eIF2α Pathway

Z Shen, C Chen, Y Yang, Z Xie, Q Ao, L Lv… - Journal of …, 2021 - Am Soc Microbiol
African swine fever virus (ASFV) is one of the most contagious and lethal viruses infecting
pigs. This virus is endemic in many countries and has very recently spread to China, but no …

Deletion of the K145R and DP148R genes from the virulent ASFV Georgia 2007/1 isolate delays the onset, but does not reduce severity, of clinical signs in infected …

A Rathakrishnan, AL Reis, LC Goatley, K Moffat… - Viruses, 2021 - mdpi.com
African swine fever virus causes a frequently fatal disease of domestic pigs and wild boar
that has a high economic impact across 3 continents. The large double-stranded DNA …

GS-441524 inhibits African swine fever virus infection in vitro

Z Huang, L Gong, Z Zheng, Q Gao, X Chen, Y Chen… - Antiviral Research, 2021 - Elsevier
African swine fever virus (ASFV) is a highly infectious and lethal swine pathogen that causes
serious socio-economic consequences in endemic countries for which no safe and effective …

Combined short and long-read sequencing reveals a complex transcriptomic architecture of African swine fever virus

G Torma, D Tombácz, Z Csabai, N Moldován… - Viruses, 2021 - mdpi.com
African swine fever virus (ASFV) is a large DNA virus belonging to the Asfarviridae family.
Despite its agricultural importance, little is known about the fundamental molecular …

1. African swine fever (ASF), the pig health challenge of the century

C Martins, FS Boinas, L Iacolina, F Ruiz-Fons… - … and Combatting African …, 2021 - brill.com
More than one hundred years ago African swine fever (ASF) was first diagnosed in Kenya.
Since then, diverse approaches have been applied to the study of the causative virus, the …