The diverse cellular functions of inner nuclear membrane proteins
S Pawar, U Kutay - Cold Spring Harbor Perspectives in …, 2021 - cshperspectives.cshlp.org
The nuclear compartment is delimited by a specialized expanded sheet of the endoplasmic
reticulum (ER) known as the nuclear envelope (NE). Compared to the outer nuclear …
reticulum (ER) known as the nuclear envelope (NE). Compared to the outer nuclear …
Ventricular voltage‐gated ion channels: Detection, characteristics, mechanisms, and drug safety evaluation
L Chen, Y He, X Wang, J Ge, H Li - Clinical and Translational …, 2021 - Wiley Online Library
Cardiac voltage‐gated ion channels (VGICs) play critical roles in mediating cardiac
electrophysiological signals, such as action potentials, to maintain normal heart excitability …
electrophysiological signals, such as action potentials, to maintain normal heart excitability …
Differential modulation of SK channel subtypes by phosphorylation
Abstract Small-conductance Ca 2+-activated K+(SK) channels are voltage-independent and
are activated by Ca 2+ binding to the calmodulin constitutively associated with the channels …
are activated by Ca 2+ binding to the calmodulin constitutively associated with the channels …
[HTML][HTML] Consensus channelome of dinoflagellates revealed by transcriptomic analysis sheds light on their physiology
Ion channels are membrane protein complexes mediating passive ion flux across the cell
membranes. Every organism has a certain set of ion channels that define its physiology …
membranes. Every organism has a certain set of ion channels that define its physiology …
[HTML][HTML] Structure-function relationships and modifications of cardiac sarcoplasmic reticulum Ca2+-transport
M Nusier, NS DHALLA - Physiological Research, 2021 - ncbi.nlm.nih.gov
Sarcoplasmic reticulum (SR) is a specialized tubular network, which not only maintains the
intracellular concentration of Ca 2+ at a low level but is also known to release and …
intracellular concentration of Ca 2+ at a low level but is also known to release and …
Knocking out TMEM38B in human foetal osteoblasts hFOB 1.19 by CRISPR/Cas9: A model for recessive OI type XIV
L Leoni, F Tonelli, R Besio, R Gioia, F Moccia, A Rossi… - Plos one, 2021 - journals.plos.org
Osteogenesis imperfecta (OI) type XIV is a rare recessive bone disorder characterized by
variable degree of severity associated to osteopenia. It is caused by mutations in TMEM38B …
variable degree of severity associated to osteopenia. It is caused by mutations in TMEM38B …
TRIC-A regulates intracellular Ca2+ homeostasis in cardiomyocytes
Trimeric intracellular cation (TRIC) channels have been identified as monovalent cation
channels that are located in the ER/SR membrane. Two isoforms discovered in mammals …
channels that are located in the ER/SR membrane. Two isoforms discovered in mammals …
Multi-omics approach to dissect the mechanisms of rexinoid signaling in myoblast differentiation
S Khilji, Y Li, J Chen, Q Li - Frontiers in Pharmacology, 2021 - frontiersin.org
Stem cells represent a key resource in regenerative medicine, however, there is a critical
need for pharmacological modulators to promote efficient conversion of stem cells into a …
need for pharmacological modulators to promote efficient conversion of stem cells into a …
[HTML][HTML] Detection of a recurrent TMEM38B gene deletion associated with recessive osteogenesis imperfecta
Osteogenesis imperfecta is a clinically and genetically group of heterogeneous disorders
associated with decreased bone density, brittle bones, bone deformity, recurrent fractures …
associated with decreased bone density, brittle bones, bone deformity, recurrent fractures …
Elucidation of the Physiological Functions of Membrane Proteins as Novel Drug Target Candidate Molecules
A Ichimura - Biological and Pharmaceutical Bulletin, 2021 - jstage.jst.go.jp
For pharmaceutical research focused on identifying novel drug target candidate molecules,
it is essential to explore unknown biological phenomena, elucidate underlying molecular …
it is essential to explore unknown biological phenomena, elucidate underlying molecular …