The nuclear compartment is delimited by a specialized expanded sheet of the endoplasmic
reticulum (ER) known as the nuclear envelope (NE). Compared to the outer nuclear …

Cardiac voltage‐gated ion channels (VGICs) play critical roles in mediating cardiac
electrophysiological signals, such as action potentials, to maintain normal heart excitability …

Abstract Small-conductance Ca 2+-activated K+(SK) channels are voltage-independent and
are activated by Ca 2+ binding to the calmodulin constitutively associated with the channels …

Ion channels are membrane protein complexes mediating passive ion flux across the cell
membranes. Every organism has a certain set of ion channels that define its physiology …

Sarcoplasmic reticulum (SR) is a specialized tubular network, which not only maintains the
intracellular concentration of Ca 2+ at a low level but is also known to release and …

Osteogenesis imperfecta (OI) type XIV is a rare recessive bone disorder characterized by
variable degree of severity associated to osteopenia. It is caused by mutations in TMEM38B …

Trimeric intracellular cation (TRIC) channels have been identified as monovalent cation
channels that are located in the ER/SR membrane. Two isoforms discovered in mammals …

Stem cells represent a key resource in regenerative medicine, however, there is a critical
need for pharmacological modulators to promote efficient conversion of stem cells into a …

Osteogenesis imperfecta is a clinically and genetically group of heterogeneous disorders
associated with decreased bone density, brittle bones, bone deformity, recurrent fractures …

For pharmaceutical research focused on identifying novel drug target candidate molecules,
it is essential to explore unknown biological phenomena, elucidate underlying molecular …