Nuclear factor erythroid 2-related factor (Nrf2) is a transcriptional activator of the cell
protection gene that binds to the antioxidant response element (ARE). Therefore, Nrf2 …

Hormesis is any kind of biphasic dose-response when low doses of some agents are
beneficial while higher doses are detrimental. Radiation hormesis is the most thoroughly …

Purpose Phase 1 clinical trials have established low-dose, whole-lung radiation therapy (LD-
RT) as safe for patients with coronavirus disease 2019 (COVID-19)-related pneumonia. By …

Novel mechanistic insights are discussed herein that link a single, nontoxic, low-dose
radiotherapy (LDRT) treatment (0.5–1.0 Gy) to (1) beneficial subcellular effects mediated by …

Objectives This review aims to trace the historical narrative surrounding the low dose effects
of radiation on the immune system and how our understanding has changed from the …

Background and purpose The main cause of death in COVID-19 pneumonia is acute
respiratory distress syndrome which is preceded by massive cytokine release. Low-dose …

Background Low-dose radiotherapy (LD-RT) has produced anti-inflammatory effects in both
animal models and early human trials of COVID-19-related pneumonia. The role of whole …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative pathogen of
the coronavirus disease 2019 (COVID-19), has caused more than 179 million infections and …

Simple Summary There are limited available data indicating that in oxygen-dependent
elderly patients with COVID-19-associated pneumonia, low-dose whole-lung radiation …

Background Osteoarthritis (OA), the most common degenerative joint disease, is associated
with severe functional limitation and impairment of quality of life. Numerous reports have …