[HTML][HTML] Platforms for production of protein-based vaccines: from classical to next-generation strategies

R Cid, J Bolívar - Biomolecules, 2021 - mdpi.com
To date, vaccination has become one of the most effective strategies to control and reduce
infectious diseases, preventing millions of deaths worldwide. The earliest vaccines were …

[HTML][HTML] Peptide-based supramolecular vaccine systems

CL O'Neill, PC Shrimali, ZE Clapacs, MA Files… - Acta biomaterialia, 2021 - Elsevier
Currently approved replication-competent and inactivated vaccines are limited by excessive
reactogenicity and poor safety profiles, while subunit vaccines are often insufficiently …

Sustainability of neutralising antibodies induced by bivalent or quadrivalent HPV vaccines and correlation with efficacy: a combined follow-up analysis of data from two …

FC Mariz, P Gray, N Bender, T Eriksson… - The Lancet Infectious …, 2021 - thelancet.com
Background Quadrivalent and bivalent vaccines against oncogenic human papillomavirus
(HPV) are used worldwide with different reported overall efficacies against HPV infections …

[HTML][HTML] RG1-VLP and other L2-based, broad-spectrum HPV vaccine candidates

B Huber, JW Wang, RBS Roden… - Journal of Clinical …, 2021 - mdpi.com
Licensed human papillomavirus (HPV) vaccines contain virus-like particles (VLPs) self-
assembled from L1 major-capsid proteins that are remarkably effective prophylactic …

Advancements in molecular design and bioprocessing of recombinant adeno‐associated virus gene delivery vectors using the insect‐cell baculovirus expression …

PRH Joshi, A Venereo‐Sanchez… - Biotechnology …, 2021 - Wiley Online Library
Despite rapid progress in the field, scalable high‐yield production of adeno‐associated virus
(AAV) is still one of the critical bottlenecks the manufacturing sector is facing. The insect cell …

[HTML][HTML] Current status of human papillomavirus-related head and neck cancer: from viral genome to patient care

H Dong, X Shu, Q Xu, C Zhu, AM Kaufmann, ZM Zheng… - Virologica Sinica, 2021 - Springer
Human papillomavirus (HPV) infection identified as a definitive human carcinogen is
increasingly being recognized for its role in carcinogenesis of human cancers. Up to 38 …

[HTML][HTML] The contribution of bovines to human health against viral infections

ARA Saied, AA Metwally, HMA Mohamed… - … Science and Pollution …, 2021 - Springer
In the last 40 years, novel viruses have evolved at a much faster pace than other pathogens.
Viral diseases pose a significant threat to public health around the world. Bovines have a …

[HTML][HTML] High resolution cryo EM analysis of HPV16 identifies minor structural protein L2 and describes capsid flexibility

DJ Goetschius, SR Hartmann, S Subramanian… - Scientific reports, 2021 - nature.com
Human papillomavirus (HPV) is a significant health burden and leading cause of virus-
induced cancers. HPV is epitheliotropic and its replication is tightly associated with terminal …

Targeted next generation sequencing panel for HPV genotyping in cervical cancer

J Lippert, S Bønløkke, A Utke, BR Knudsen… - Experimental and …, 2021 - Elsevier
Cervical cancer are generally caused by a persistent infection with the oncogenic virus,
HPV. Patients with HPV integration are more prone to develop cervical cancer than patients …

[HTML][HTML] Phytochemicals as potential chemopreventive and chemotherapeutic agents for emerging human papillomavirus–driven head and neck cancer: Current …

N Aggarwal, J Yadav, S Chhakara, D Janjua… - Frontiers in …, 2021 - frontiersin.org
Head and neck cancer (HNC) usually arises from squamous cells of the upper aerodigestive
tract that line the mucosal surface in the head and neck region. In India, HNC is common in …