Genetic susceptibility of hypertension‐induced kidney disease

C Zhang, X Fang, H Zhang, W Gao, HJ Hsu… - Physiological …, 2021 - Wiley Online Library
Hypertension is the second leading cause of end‐stage renal disease (ESRD) after diabetes
mellitus. The significant differences in the incidence of hypertensive ESRD between different …

The mononuclear phagocyte system of the rat

DA Hume, M Caruso, S Keshvari, OL Patkar… - The Journal of …, 2021 - journals.aai.org
The laboratory rat continues to be the model of choice for many studies of physiology,
behavior, and complex human diseases. Cells of the mononuclear phagocyte system (MPS; …

Role of γ-adducin in actin cytoskeleton rearrangements in podocyte pathophysiology

W Gao, Y Liu, L Fan, B Zheng… - American Journal …, 2021 - journals.physiology.org
We recently reported that the enhanced susceptibility to chronic kidney disease (CKD) in the
fawn-hooded hypertensive (FHH) rat is caused, at least in part, by a mutation in γ-adducin …

Knockout of γ-adducin promotes NG-nitro-L-arginine-methyl-ester–induced hypertensive renal injury

L Fan, W Gao, Y Liu, JR Jefferson, F Fan… - Journal of Pharmacology …, 2021 - ASPET
Previous studies identified a region on chromosome 1 associated with NG-nitro-L-arginine
methyl ester (L-NAME) hypertension-induced renal disease in fawn-hooded hypertensive …