Fibroblasts as immune regulators in infection, inflammation and cancer
In chronic infection, inflammation and cancer, the tissue microenvironment controls how
local immune cells behave, with tissue-resident fibroblasts emerging as a key cell type in …
local immune cells behave, with tissue-resident fibroblasts emerging as a key cell type in …
The aftermath of the interplay between the endoplasmic reticulum stress response and redox signaling
KR Bhattarai, TA Riaz, HR Kim, HJ Chae - Experimental & molecular …, 2021 - nature.com
The endoplasmic reticulum (ER) is an essential organelle of eukaryotic cells. Its main
functions include protein synthesis, proper protein folding, protein modification, and the …
functions include protein synthesis, proper protein folding, protein modification, and the …
[HTML][HTML] The complement system drives local inflammatory tissue priming by metabolic reprogramming of synovial fibroblasts
J Friščić, M Böttcher, C Reinwald, H Bruns, B Wirth… - Immunity, 2021 - cell.com
Arthritis typically involves recurrence and progressive worsening at specific predilection
sites, but the checkpoints between remission and persistence remain unknown. Here, we …
sites, but the checkpoints between remission and persistence remain unknown. Here, we …
Molecular and cellular heterogeneity in rheumatoid arthritis: mechanisms and clinical implications
Rheumatoid arthritis is an autoimmune disease that exhibits significant clinical
heterogeneity. There are various treatments for rheumatoid arthritis, including disease …
heterogeneity. There are various treatments for rheumatoid arthritis, including disease …
Location, location, location: how the tissue microenvironment affects inflammation in RA
Current treatments for rheumatoid arthritis (RA) do not work well for a large proportion of
patients, or at all in some individuals, and cannot cure or prevent this disease. One major …
patients, or at all in some individuals, and cannot cure or prevent this disease. One major …
Toll-like receptors as a therapeutic target in the era of immunotherapies
Toll-like receptors (TLRs) are the pattern recognition receptors, which are activated by
foreign and host molecules in order to initiate the immune response. They play a crucial role …
foreign and host molecules in order to initiate the immune response. They play a crucial role …
New insights from single-cell sequencing data: Synovial fibroblasts and synovial macrophages in rheumatoid arthritis
L Cheng, Y Wang, R Wu, T Ding, H Xue, C Gao… - Frontiers in …, 2021 - frontiersin.org
Single-cell RNA sequencing (scRNA-seq) technology can analyze the transcriptome
expression level of cells with high-throughput from the single cell level, fully show the …
expression level of cells with high-throughput from the single cell level, fully show the …
Increasing toll-like receptor 2 on astrocytes induced by Schwann cell-derived exosomes promotes recovery by inhibiting CSPGs deposition after spinal cord injury
Background Traumatic spinal cord injury (SCI) is a severely disabling disease that leads to
loss of sensation, motor, and autonomic function. As exosomes have great potential in …
loss of sensation, motor, and autonomic function. As exosomes have great potential in …
Fibroblast pathology in inflammatory joint disease
Rheumatoid arthritis is an immune‐mediated inflammatory disease in which fibroblasts
contribute to both joint damage and inflammation. Fibroblasts are a major cell constituent of …
contribute to both joint damage and inflammation. Fibroblasts are a major cell constituent of …
Targeting AhR as a novel therapeutic modality against inflammatory diseases
For decades, activation of Aryl Hydrocarbon Receptor (AhR) was excluded from
consideration as a therapeutic approach due to the potential toxic effects of AhR ligands and …
consideration as a therapeutic approach due to the potential toxic effects of AhR ligands and …