The molecular features that define clear cell renal cell carcinoma (ccRCC) initiation and
progression are being increasingly defined. The TRACERx Renal studies and others that …

Hematologic malignancies include various diseases that develop from hematopoietic stem
cells of bone marrow or lymphatic organs. Currently, conventional DNA-damage-based …

Renal cell carcinoma (RCC) is a malignant tumor of the kidneys. Approximately 70% of RCC
cases are clear cell renal cell carcinoma with von Hippel–Lindau (VHL) gene mutation and …

Over the last decades, the growing understanding on DNA damage response (DDR)
pathways has broadened the therapeutic landscape in oncology. It is becoming increasingly …

The replication stress response (RSR) involves a downstream kinase cascade comprising
ataxia telangiectasia-mutated (ATM), ATM and rad3-related (ATR), checkpoint kinases 1 and …

Cell cycle checkpoints secure ordered progression from one cell cycle phase to the next.
They are important to signal cell stress and DNA lesions and to stop cell cycle progression …

Histone modification is an important form of epigenetic regulation. Thereinto, histone
methylation is a critical determination of chromatin states, participating in multiple cellular …

Ribonucleotide reductase (RR) is a unique enzyme for the reduction of NDPs to dNDPs, the
building blocks for DNA synthesis and thus essential for cell proliferation. Pan-cancer …

Hotspot histone H3 mutations have emerged as drivers of oncogenesis in cancers of
multiple lineages. Specifically, H3 lysine 36 to methionine (H3K36M) mutations are …

Background and Aims Trimethylation of Lys36 on histone 3 (H3K36me3) catalyzed by
histone methyltransferase SET domain‐containing 2 (SETD2) is one of the most conserved …