Migraine is the sixth most prevalent disease globally, a major cause of disability, and it
imposes an enormous personal and socio‐economic burden. Migraine treatment is often …

Cluster headache is a debilitating primary headache disorder that affects approximately
0.1% of the population worldwide. Cluster headache attacks involve severe unilateral pain …

Objective To evaluate the efficacy, tolerability, and safety of eptinezumab 100 and 300 mg
compared with placebo in patients with the dual diagnosis of chronic migraine (CM) and …

Migraine is a common disabling primary headache disorder that is ranked as the most
common neurological cause of disability worldwide. Women present with migraine much …

The parabrachial nucleus (PB) is composed of glutamatergic neurons at the midbrain–
hindbrain junction. These neurons form many subpopulations, one of which expresses …

Background Central sensitization is an important pathophysiological mechanism of chronic
migraine (CM). According to our previous studies, microglial activation and subsequent …

Pathophysiology of Migraine : CONTINUUM: Lifelong Learning in Neurology Account Register
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Abstract Background & Objective To conduct a systematic review and network meta-analysis
of all randomized trials investigating effects of anti-calcitonin gene related peptide …

The neuropeptides CGRP (calcitonin gene-related peptide) and PACAP (pituitary adenylate
cyclase-activating polypeptide) have emerged as mediators of migraine, yet the potential …

Background Photophobia is a potentially debilitating symptom often found in dry eye
disease (DE), migraine and traumatic brain injury (TBI). Methods We conducted a review of …