[HTML][HTML] Protective role of taurine against oxidative stress

S Baliou, M Adamaki, P Ioannou… - Molecular …, 2021 - build.spandidos-publications.com
Taurine is a fundamental mediator of homeostasis that exerts multiple roles to confer
protection against oxidant stress. The development of hypertension, muscle/neuro‑​ …

[HTML][HTML] Recommendations for the use of the acetaminophen hepatotoxicity model for mechanistic studies and how to avoid common pitfalls

H Jaeschke, OB Adelusi, JY Akakpo, NT Nguyen… - … Pharmaceutica Sinica B, 2021 - Elsevier
Acetaminophen (APAP) is a widely used analgesic and antipyretic drug, which is safe at
therapeutic doses but can cause severe liver injury and even liver failure after overdoses …

Drug‐induced liver injury: clinical evidence of N‐acetyl cysteine protective effects

Y Ntamo, K Ziqubu, N Chellan… - Oxidative medicine …, 2021 - Wiley Online Library
Oxidative stress is a key pathological feature implicated in both acute and chronic liver
diseases, including drug‐induced liver injury (DILI). The latter describes hepatic injury …

Protective role of Chlorella vulgaris with Thiamine against Paracetamol induced toxic effects on haematological, biochemical, oxidative stress parameters and …

AAE Latif, DH Assar, EM Elkaw, HA Hamza… - Scientific Reports, 2021 - nature.com
Paracetamol is extensively consumed as an analgesic and antipyretic drug, but at a high
dose level, it leads to deleterious side effects, such as hepatic and nephrotoxicity. This …

Oxidant stress and acetaminophen hepatotoxicity: mechanism-based drug development

A Ramachandran, H Jaeschke - Antioxidants & redox signaling, 2021 - liebertpub.com
Significance: Acetaminophen (APAP) is one of the quantitively most consumed drugs
worldwide. Although safe at therapeutic doses, intentional or unintentional overdosing …

Roles of Suaeda vermiculata Aqueous‐Ethanolic Extract, Its Subsequent Fractions, and the Isolated Compounds in Hepatoprotection against Paracetamol‐Induced …

SAA Mohammed, HM Ali… - Oxidative Medicine …, 2021 - Wiley Online Library
Suaeda vermiculata, a halophyte consumed by livestock, is also used by Bedouins to
manage liver disorders. The aqueous‐ethanolic extract of S. vermiculata, its subsequent …

Plasmin-mediated cleavage of high-molecular-weight kininogen contributes to acetaminophen-induced acute liver failure

MW Henderson, EM Sparkenbaugh… - Blood, The Journal …, 2021 - ashpublications.org
Acetaminophen (APAP)-induced liver injury is associated with activation of coagulation and
fibrinolysis. In mice, both tissue factor–dependent thrombin generation and plasmin activity …

Removal of paracetamol from aqueous solution by containment composites

S Ait Hamoudi, M Brahimi, M Boucha, B Hamdi… - Open …, 2021 - degruyter.com
Storage of wastes leads to severe problems of water pollution and neighboring matrices due
to the infiltration of landfill leachate. Uncontrolled landfill and waste storage can lead to …

The dual role of immune response in acetaminophen hepatotoxicity: Implication for immune pharmacological targets

L Gong, L Liao, X Dai, X Xue, C Peng, Y Li - Toxicology Letters, 2021 - Elsevier
Acetaminophen (APAP), one of the most widely used antipyretic and analgesic drugs,
principally contributes to drug-induced liver injury when taken at a high dose. APAP-induced …

Effects of paracetamol on the polychaete Hediste diversicolor: occurrence of oxidative stress, cyclooxygenase inhibition and behavioural alterations

AF Nogueira, B Nunes - Environmental Science and Pollution Research, 2021 - Springer
Pharmaceuticals are significant environmental stressors, since they are utilized around the
world; they are usually released in to the aquatic system without adequate treatment and …