Incorporation of heterocycles into drug molecules can enhance physical properties and
biological activity. A variety of heterocyclic groups is available to medicinal chemists, many …

Biosurfactants are natural compounds produced biologically by certain bacterial strains.
They are promising alternatives in several applications due to their biocompatibility …

As a transcription factor and proto-oncogene, MYC is known to be deregulated in a variety of
tumors, including breast cancer. However, no consistent conclusion on the role and …

Background/Aim: Successful therapy of EGFR-mutant NSCLC remains a challenging task
despite initial benefits with the usage of EGFR tyrosine kinase inhibitors. Cancer …

Background: AKT/PKB is an important enzyme with numerous biological functions, and its
overexpression is related to carcinogenesis. AKT stimulates different signaling pathways …

The AKT protein kinase plays a central role in several interconnected molecular pathways
involved in growth, apoptosis, angiogenesis, and cell metabolism. It thereby represents a …

Full article: Discovery of new AKT1 inhibitors by combination of in silico structure based virtual
screening approaches and biological evaluations Skip to Main Content Taylor and Francis …

Non-small-cell lung cancer (NSCLC) with Kirsten RAt Sarcoma 2 viral oncogene homolog
(KRAS) mutation has become a clinical challenge in cancer treatment as KRAS-mutant …

Simple Summary The PTEN/AKT pathway is involved in several human and animal tumors'
pathogenesis. This study investigates the PTEN/AKT pathway's biological and prognostic …

The Sonochemical synthesis of a library of 3-methyleneisoindolin-1-one based novel small
molecules derived from rosuvastatin designed as potential anticancer agents was …