[HTML][HTML] Role of microbiota-derived short-chain fatty acids in nervous system disorders

R Mirzaei, B Bouzari, SR Hosseini-Fard… - Biomedicine & …, 2021 - Elsevier
During the past decade, accumulating evidence from the research highlights the suggested
effects of bacterial communities of the human gut microbiota and their metabolites on health …

Psychedelics in psychiatry: neuroplastic, immunomodulatory, and neurotransmitter mechanisms

A Inserra, D De Gregorio, G Gobbi - Pharmacological Reviews, 2021 - ASPET
Mounting evidence suggests safety and efficacy of psychedelic compounds as potential
novel therapeutics in psychiatry. Ketamine has been approved by the Food and Drug …

[HTML][HTML] NLRP3/caspase-1/GSDMD–mediated pyroptosis exerts a crucial role in astrocyte pathological injury in mouse model of depression

S Li, Y Sun, M Song, Y Song, Y Fang, Q Zhang, X Li… - JCI insight, 2021 - ncbi.nlm.nih.gov
Emerging evidence suggests that astrocyte loss is one of the most important pathological
features in the hippocampus of patients with major depressive disorder (MDD) and …

Gut microbiota modulates the inflammatory response and cognitive impairment induced by sleep deprivation

Z Wang, WH Chen, SX Li, ZM He, WL Zhu, YB Ji… - Molecular …, 2021 - nature.com
Sleep deprivation (SD) is increasingly common in modern society, which can lead to the
dysregulation of inflammatory responses and cognitive impairment, but the mechanisms …

Gut microbiota–brain axis in depression: The role of neuroinflammation

AS Carlessi, LA Borba, AI Zugno… - European Journal of …, 2021 - Wiley Online Library
Major depressive disorder (MDD) is a psychiatric condition that affects a large number of
people in the world, and the treatment existents do not work for all individuals affected. Thus …

A role of the subdiaphragmatic vagus nerve in depression-like phenotypes in mice after fecal microbiota transplantation from Chrna7 knock-out mice with depression …

Y Pu, Y Tan, Y Qu, L Chang, S Wang, Y Wei… - Brain, Behavior, and …, 2021 - Elsevier
The α7 subtype of the nicotinic acetylcholine receptor (α7 nAChR: coded by Chrna7)
regulates the cholinergic ascending anti-inflammatory pathway involved in depression. We …

Antidepressant effect of paeoniflorin is through inhibiting pyroptosis CASP-11/GSDMD pathway

DD Tian, M Wang, A Liu, MR Gao, C Qiu, W Yu… - Molecular …, 2021 - Springer
Nod-like receptor protein 3 (NLRP3)-associated neuroinflammation mediated by activated
microglia is involved in the pathogenesis of depression. The role of the pore-forming protein …

[HTML][HTML] The role of the gut microbiome in the development of schizophrenia

JR Kelly, C Minuto, JF Cryan, G Clarke… - Schizophrenia Research, 2021 - Elsevier
Schizophrenia is a heterogeneous neurodevelopmental disorder involving the convergence
of a complex and dynamic bidirectional interaction of genetic expression and the …

[HTML][HTML] Cancer and stress: NextGen strategies

B Cui, F Peng, J Lu, B He, Q Su, H Luo, Z Deng… - Brain, Behavior, and …, 2021 - Elsevier
Chronic stress is well-known to cause physiological distress that leads to body balance
perturbations by altering signaling pathways in the neuroendocrine and sympathetic …

Effects of microbiota imbalance in anxiety and eating disorders: probiotics as novel therapeutic approaches

E Navarro-Tapia, L Almeida-Toledano… - International journal of …, 2021 - mdpi.com
Anxiety and eating disorders produce a physiological imbalance that triggers alterations in
the abundance and composition of gut microbiota. Moreover, the gut–brain axis can be …