The known seven mammalian receptor subunits (P2X1–7) form cationic channels gated by
ATP. Three subunits compose a receptor channel. Each subunit is a polypeptide consisting …

Predicting the sensitivity of tumors to specific anti-cancer treatments is a challenge of
paramount importance for precision medicine. Machine learning (ML) algorithms can be …

We developed an endophenotype disease module-based methodology for Alzheimer's
disease (AD) drug repurposing and identified sildenafil as a potential disease risk modifier …

Background and Purpose Cancer cells exhibit more dependence on iron and enhanced
sensitivity to iron‐dependent, programmed cell death (ferroptosis) than normal cells …

The process of mitochondrial dynamics is emerging as a core player in cardiovascular
homeostasis. This process refers to the co‐ordinated cycles of biogenesis, fusion, fission …

Background and Purpose Oxidative stress and neuronal apoptosis play key roles in
traumatic brain injury. We investigated the protective effects of astaxanthin against traumatic …

Efficient therapies are available for the treatment of osteoporosis. Anti‐resorptive therapies,
including bisphosphonates and denosumab, increase bone mineral density (BMD) and …

Histamine receptors play important roles in various pathophysiological conditions and are
effective targets for anti-allergy treatment, however the mechanism of receptor activation …

G protein‐coupled receptors (GPCRs) play critical roles in the regulation of human
physiology in response to a wide array of different extracellular stimuli and thus represent …

The development of multidrug‐resistant bacteria has revealed the need for new
antimicrobial compounds. Cannabis sativa preparations have a long history of medical …