There is a genetic component to human obesity that accounts for 40% to 50% of the
variability in body weight status but that is lower among normal weight individuals (about …

Background Glucose-dependent insulinotropic peptide (GIP) is one of two incretin hormones
that communicate nutrient intake with systemic metabolism. Although GIP was the first …

Background Biological aging estimators derived from DNA methylation data are heritable
and correlate with morbidity and mortality. Consequently, identification of genetic and …

Objectives Recent studies suggested obesity to be a possible risk factor for COVID-19
disease in the wake of the coronavirus (SARS-CoV-2) infection. However, the causality and …

A key assumption of Mendelian randomization (MR) analysis is that there is no association
between the genetic variants used as instruments and the outcome other than through the …

Age at menarche (AAM) is an important marker of the pubertal development and function of
the hypothalamic–pituitary–ovarian system. It was reported as a possible factor for a risk of …

Observational studies suggest smoking, cannabis use, alcohol consumption, and substance
use disorders (SUDs) may impact risk for respiratory infections, including coronavirus 2019 …

Importance Smoking is associated with atherosclerotic cardiovascular disease, but the
relative contribution to each subtype (coronary artery disease [CAD], peripheral artery …

Preferential fat accumulation in visceral vs. subcutaneous depots makes obese individuals
more prone to metabolic complications. Body fat distribution (FD) is regulated by genetics …

The Duroc×(Landrace× Yorkshire) hybrid pigs (DLY) are the most popular commercial pigs,
providing consumers with the largest source of pork. In order to gain more insights into the …