Huntington's disease (HD) is a neurodegenerative disorder caused by a CAG expansion in
the HD gene. The disease is characterized by neurodegeneration, particularly in the striatum …

Huntington's disease (HD) is an adult-onset neurodegenerative disease caused by a
trinucleotide CAG repeat expansion in the HTT gene. While the pathogenesis of HD is …

We used behavioral testing and morphological methods to detail the progression of basal
ganglia neuron type‐specific pathology and the deficits stemming from them in male …

Mitochondrial dysfunction and bioenergetics failure are common pathological hallmarks in
Huntington's disease (HD) and aging. In the present study, we used the YAC128 murine …

2022-01-07 First worldwide family litigation filed litigation Critical https://patents. darts-ip.
com/? family= 53189202&utm_source= google_patent&utm_medium …

The present study describes evaluation of epigenetic regulation by a small molecule as the
therapeutic potential for treatment of Huntington's disease (HD). We identified 5-allyloxy-2 …

Mouse models are frequently used to study Huntington's disease (HD). The onset and
severity of neuronal and behavioral pathologies vary greatly between HD mouse models …

The axon enables long distance travel of electrical and chemical information between
neurons, a process at the basis of neuronal communication and brain function. This …

NMDA and AMPA-type glutamate receptors and their bound membrane-associated
guanylate kinases (MAGUKs) are critical for synapse development and plasticity. We …

Effects of GluN3A silencing in Huntington's disease and systematic mapping of its expression in
the mouse forebrain Page 1 Effects of GluN3A silencing in Huntington's disease and systematic …