Critical role of SMG7 in activation of the ATR-CHK1 axis in response to genotoxic stress
K Ho, H Luo, W Zhu, Y Tang - Scientific Reports, 2021 - nature.com
CHK1 is a crucial DNA damage checkpoint kinase and its activation, which requires ATR
and RAD17, leads to inhibition of DNA replication and cell cycle progression. Recently, we …
and RAD17, leads to inhibition of DNA replication and cell cycle progression. Recently, we …
Nuclear translocation promotes proteasomal degradation of human Rad17 protein through the N-terminal destruction boxes
Y Fukumoto, M Ikeuchi, L Qu, T Hoshino… - Journal of Biological …, 2021 - ASBMB
The ATR pathway is one of the major DNA damage checkpoints, and Rad17 is a DNA-
binding protein that is phosphorylated upon DNA damage by ATR kinase. Rad17 recruits …
binding protein that is phosphorylated upon DNA damage by ATR kinase. Rad17 recruits …
Rad24-RFC loads the 9-1-1 clamp by inserting DNA from the top of a wide-open ring, opposite the mechanism of RFC/PCNA
F Zheng, RE Georgescu, NY Yao, ME O'Donnell, H Li - bioRxiv, 2021 - biorxiv.org
In response to DNA damage, the ring-shaped 9-1-1 clamp is loaded onto 5'recessed DNA to
arrest the cell cycle and activate the DNA damage checkpoint. The 9-1-1 clamp is a …
arrest the cell cycle and activate the DNA damage checkpoint. The 9-1-1 clamp is a …