Cardiac myosin is the molecular motor that powers heart contraction by converting chemical
energy from ATP hydrolysis into mechanical force. The power output of the heart is tightly …

The spontaneous activity of the sinoatrial node initiates the heartbeat. Sino-atrial node
dysfunction (SND) and sick sinoatrial (sick sinus) syndrome are caused by the heart's …

Importance Early-onset atrial fibrillation (AF) can be the initial manifestation of a more
serious underlying inherited cardiomyopathy or arrhythmia syndrome. Objective To examine …

Sequencing of large cohorts offers an unprecedented opportunity to identify rare genetic
variants and to find novel contributors to human disease. We used gene-based collapsing …

Importance Although rare variants in cardiac ion channels, transcription factors, and
myocardial structural proteins are associated with early-onset atrial fibrillation (AF) in White …

Aims The aim of this study was to use human genetics to investigate the pathogenesis of
sick sinus syndrome (SSS) and the role of risk factors in its development. Methods and …

The pacemaker cells of the cardiac sinoatrial node (SAN) are essential for normal cardiac
automaticity. Dysfunction in cardiac pacemaking results in human sinoatrial node …

The prevalence and economic burden of atrial fibrillation (AF) are predicted to more than
double over the next few decades. In addition to anticoagulation and treatment of …

The atrioventricular canal (AVC) is the site where key structures responsible for functional
division between heart regions are established, most importantly, the atrioventricular (AV) …

Background The whole exome sequencing (WES) with targeted gene analysis is an effective
diagnostic tool for cardiomyopathy. The early‐onset sudden cardiac death (SCD) was …