MALDI-MSI analysis of cancer drugs: Significance, advances, and applications
Q He, C Sun, J Liu, Y Pan - TrAC Trends in Analytical Chemistry, 2021 - Elsevier
Because of the heterogeneity and complexity of tumor structure, cancer drugs often cannot
effectively reach the tumor, which is one of the reasons for drug resistance and treatment …
effectively reach the tumor, which is one of the reasons for drug resistance and treatment …
High-resolution imaging and identification of biomolecules using Nano-DESI coupled to ion mobility spectrometry
Simultaneous spatial localization and structural characterization of molecules in complex
biological samples currently represents an analytical challenge for mass spectrometry …
biological samples currently represents an analytical challenge for mass spectrometry …
Visualizing and quantifying antimicrobial drug distribution in tissue
The biodistribution and pharmacokinetics of drugs are vital to the mechanistic understanding
of their efficacy. Measuring antimicrobial drug efficacy has been challenging as plasma drug …
of their efficacy. Measuring antimicrobial drug efficacy has been challenging as plasma drug …
Hydralazine as a versatile and universal matrix for high-molecular coverage and dual-polarity matrix-assisted laser desorption/ionization mass spectrometry imaging
Few matrices have the potential to be universally applicable for imaging vast endogenous
compounds ranging from micro to macromolecules. In this article, we present hydralazine …
compounds ranging from micro to macromolecules. In this article, we present hydralazine …
Neuropharmacokinetic visualization of regional and subregional unbound antipsychotic drug transport across the blood–brain barrier
D Luptáková, T Vallianatou, A Nilsson… - Molecular …, 2021 - nature.com
Comprehensive determination of the extent of drug transport across the region-specific
blood–brain barrier (BBB) is a major challenge in preclinical studies. Multiple approaches …
blood–brain barrier (BBB) is a major challenge in preclinical studies. Multiple approaches …
Quantitative mass spectrometry imaging to study drug distribution in the intestine following oral dosing
LRS Huizing, J McDuffie, F Cuyckens… - Analytical …, 2021 - ACS Publications
Local delivery to the lower gut to treat diseases of the colon has become a topic of special
attention. Tissue exposure of locally acting agents is not represented by plasma …
attention. Tissue exposure of locally acting agents is not represented by plasma …
Matrix ions as internal standard for high mass accuracy matrix‐assisted laser desorption/ionization mass spectrometry imaging
A Treu, A Römpp - Rapid Communications in Mass …, 2021 - Wiley Online Library
Rationale High mass accuracy is indispensable for reliable identification in matrix‐assisted
laser desorption/ionization mass spectrometry (MALDI MS) imaging. Ubiquitous matrix ions …
laser desorption/ionization mass spectrometry (MALDI MS) imaging. Ubiquitous matrix ions …
The space dimension at the micro level: mass spectrometry imaging of drugs in tissues
Mass spectrometry imaging (MSI) has seen remarkable development in recent years. The
possibility of getting quantitative or semiquantitative data, while maintaining the spatial …
possibility of getting quantitative or semiquantitative data, while maintaining the spatial …
Holistic Characterization of a Salmonella Typhimurium Infection Model Using Integrated Molecular Imaging
N Strittmatter, P Kanvatirth, P Inglese… - Journal of the …, 2021 - ACS Publications
A more complete and holistic view on host–microbe interactions is needed to understand the
physiological and cellular barriers that affect the efficacy of drug treatments and allow the …
physiological and cellular barriers that affect the efficacy of drug treatments and allow the …
Single-cell metabolomics by mass spectrometry imaging
Multicellular organisms achieve their complex living activities through the highly organized
metabolic interplay of individual cells and tissues. This complexity has driven the need to …
metabolic interplay of individual cells and tissues. This complexity has driven the need to …