Because of the heterogeneity and complexity of tumor structure, cancer drugs often cannot
effectively reach the tumor, which is one of the reasons for drug resistance and treatment …

Simultaneous spatial localization and structural characterization of molecules in complex
biological samples currently represents an analytical challenge for mass spectrometry …

The biodistribution and pharmacokinetics of drugs are vital to the mechanistic understanding
of their efficacy. Measuring antimicrobial drug efficacy has been challenging as plasma drug …

Few matrices have the potential to be universally applicable for imaging vast endogenous
compounds ranging from micro to macromolecules. In this article, we present hydralazine …

Comprehensive determination of the extent of drug transport across the region-specific
blood–brain barrier (BBB) is a major challenge in preclinical studies. Multiple approaches …

Local delivery to the lower gut to treat diseases of the colon has become a topic of special
attention. Tissue exposure of locally acting agents is not represented by plasma …

Rationale High mass accuracy is indispensable for reliable identification in matrix‐assisted
laser desorption/ionization mass spectrometry (MALDI MS) imaging. Ubiquitous matrix ions …

Mass spectrometry imaging (MSI) has seen remarkable development in recent years. The
possibility of getting quantitative or semiquantitative data, while maintaining the spatial …

A more complete and holistic view on host–microbe interactions is needed to understand the
physiological and cellular barriers that affect the efficacy of drug treatments and allow the …

Multicellular organisms achieve their complex living activities through the highly organized
metabolic interplay of individual cells and tissues. This complexity has driven the need to …